NGUYEN, Hoang Oanh; PINSON, Patricia Recordon; ANDREOLA, Marie-Line; PAPAGNO, Laura; APPAY, Victor

doi:10.1002/eji.70003

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NGUYEN, Hoang Oanh
Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

PINSON, Patricia Recordon
Microbiologie Fondamentale et Pathogénicité [MFP]
TBM-Core [Bordeaux] [UMS3427 - INSERM US005]

ANDREOLA, Marie-Line
Microbiologie Fondamentale et Pathogénicité [MFP]
TBM-Core [Bordeaux] [UMS3427 - INSERM US005]

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European Journal of Immunology. 2025-07-01, vol. 55, n° 7, p. e70003

Résumé en anglais

The type-I interferon family is well known for its critical role in innate immunity. It comprises several members, among which IFN-α and IFN-β are the most extensively studied, with important antiviral and immune-modulatory functions. Recent findings linking autoantibodies against type-I interferons to severe COVID-19 suggest a potential role for IFN-ω in combating SARS-CoV-2 infection. However, little is known about human IFN-ω, as most research on this interferon has been conducted in feline models. Here, we demonstrate that human IFN-ω is secreted at levels comparable to those of IFN-α or IFN-β upon stimulation with inflammatory agonists and triggers a robust antiviral response, inhibiting SARS-CoV-2 infection in vitro. Moreover, IFN-ω enhances the effector functions of antigen-specific CD8 T cells primed de novo from healthy donor cells, highlighting its capacity to promote strong cellular immunity. Our results position IFN-ω as a key member of the type-I interferon family, with promising potential for therapeutic and vaccine applications.< Réduire

Mots clés en anglais

Humans

SARS-CoV-2

Interferon Type I

CD8-Positive T-Lymphocytes

Antiviral Agents

COVID-19

Interferon-alpha

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Human Type-I Interferon Omega Holds Potent Antiviral Properties and Promotes Cytolytic CD8 T Cell Responses.

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