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Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male mice
GÓMEZ-SOTRES, Paula
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
SKUPIO, Urszula
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
DALLA TOR, Tommaso
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
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Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
GÓMEZ-SOTRES, Paula
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
SKUPIO, Urszula
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
DALLA TOR, Tommaso
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
JULIO-KALAJZIC, Francisca
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
CANNICH, Astrid
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
GISQUET, Doriane
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
BELLOCCHIO, Luigi
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
MARSICANO, Giovanni
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
< Reduce
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Language
EN
Article de revue
This item was published in
Nature Communications. 2024-08-18, vol. 15, n° 1
English Abstract
Emotions and behavior can be affected by social chemosignals from conspecifics. For instance, olfactory signals from stressed individuals induce stress-like physiological and synaptic changes in naïve partners. Direct ...Read more >
Emotions and behavior can be affected by social chemosignals from conspecifics. For instance, olfactory signals from stressed individuals induce stress-like physiological and synaptic changes in naïve partners. Direct stress also alters cognition, but the impact of socially transmitted stress on memory processes is currently unknown. Here we show that exposure to chemosignals produced by stressed individuals is sufficient to impair memory retrieval in unstressed male mice. This requires astrocyte control of information in the olfactory bulb mediated by mitochondria-associated CB1 receptors (mtCB1). Targeted genetic manipulations, in vivo Ca2+ imaging and behavioral analyses reveal that mtCB1-dependent control of mitochondrial Ca2+ dynamics is necessary to process olfactory information from stressed partners and to define their cognitive consequences. Thus, olfactory bulb astrocytes provide a link between social odors and their behavioral meaning. © The Author(s) 2024.Read less <
English Keywords
Astrocytes metabolism
Behavior Animal physiology
Calcium metabolism
Cognition physiology
Memory physiology
Mice Inbred C57BL
Mitochondria metabolism
Odorants
Olfactory Bulb metabolism
Receptor
Cannabinoid CB1 metabolism
Smell physiology
Social Behavior
Stress Psychological
European Project
Mitochondrial Cannabinoid Receptors in the Brain
ANR Project
Développment d'une infrastructure française distribuée coordonnée
Involvement of the insula in the Autism neurodevelopmental disorder
Rôle du système endocannabinoïde de l'hippocampe dans le déficits de mémoire associés à l'obésité
IdEx Bordeaux - ANR-10-IDEX-0003-02/10-IDEX-0003
Involvement of the insula in the Autism neurodevelopmental disorder
Rôle du système endocannabinoïde de l'hippocampe dans le déficits de mémoire associés à l'obésité
IdEx Bordeaux - ANR-10-IDEX-0003-02/10-IDEX-0003
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