GÓMEZ-SOTRES, Paula; SKUPIO, Urszula; DALLA TOR, Tommaso; JULIO-KALAJZIC, Francisca; CANNICH, Astrid; GISQUET, Doriane; BONILLA-DEL RIO, Itziar; DRAGO, Filippo; PUENTE, Nagore; GRANDES, Pedro; BELLOCCHIO, Luigi; BUSQUETS-GARCIA, Arnau; BAINS, Jaideep S.; MARSICANO, Giovanni

doi:10.1038/s41467-024-51416-4

GÓMEZ-SOTRES, Paula
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

SKUPIO, Urszula
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

DALLA TOR, Tommaso
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

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Article de revue

Este ítem está publicado en

Nature Communications. 2024-08-18, vol. 15, n° 1

Resumen en inglés

Emotions and behavior can be affected by social chemosignals from conspecifics. For instance, olfactory signals from stressed individuals induce stress-like physiological and synaptic changes in naïve partners. Direct stress also alters cognition, but the impact of socially transmitted stress on memory processes is currently unknown. Here we show that exposure to chemosignals produced by stressed individuals is sufficient to impair memory retrieval in unstressed male mice. This requires astrocyte control of information in the olfactory bulb mediated by mitochondria-associated CB1 receptors (mtCB1). Targeted genetic manipulations, in vivo Ca2+ imaging and behavioral analyses reveal that mtCB1-dependent control of mitochondrial Ca2+ dynamics is necessary to process olfactory information from stressed partners and to define their cognitive consequences. Thus, olfactory bulb astrocytes provide a link between social odors and their behavioral meaning. © The Author(s) 2024.< Leer menos

Palabras clave en inglés

Astrocytes metabolism

Behavior Animal physiology

Calcium metabolism

Cognition physiology

Memory physiology

Mice Inbred C57BL

Mitochondria metabolism

Odorants

Olfactory Bulb metabolism

Receptor

Cannabinoid CB1 metabolism

Smell physiology

Social Behavior

Stress Psychological

URI

https://oskar-bordeaux.fr/handle/20.500.12278/206803

DOI

http://dx.doi.org/10.1038/s41467-024-51416-4

Proyecto europeo

Mitochondrial Cannabinoid Receptors in the Brain

Proyecto ANR

Développment d'une infrastructure française distribuée coordonnée
Involvement of the insula in the Autism neurodevelopmental disorder
Rôle du système endocannabinoïde de l'hippocampe dans le déficits de mémoire associés à l'obésité - ANR-23-CE14-0004
IdEx Bordeaux - ANR-10-IDEX-0003-02/10-IDEX-0003

Centros de investigación

Neurocentre Magendie - U1215

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Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male mice