Novel insights into D-Pinitol based therapies: A link between tau hyperphosphorylation and insulin resistance
| dc.rights.license | open | en_US |
| dc.contributor.author | MEDINA-VERA, Dina | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | LÓPEZ-GAMBERO, Antonio Jesús | |
| dc.contributor.author | NAVARRO, Juan Antonio | |
| dc.contributor.author | SANJUAN, Carlos | |
| dc.contributor.author | BAIXERAS, Elena | |
| dc.contributor.author | DECARA, Juan | |
| dc.contributor.author | DE FONSECA, Fernando Rodríguez | |
| dc.date.accessioned | 2025-05-19T13:43:02Z | |
| dc.date.available | 2025-05-19T13:43:02Z | |
| dc.date.issued | 2024-02 | |
| dc.identifier.issn | 1673-5374 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/206654 | |
| dc.description.abstractEn | Alzheimer's disease is a neurodegenerative disorder characterized by the amyloid accumulation in the brains of patients with Alzheimer's disease. The pathogenesis of Alzheimer's disease is mainly mediated by the phosphorylation and aggregation of tau protein. Among the multiple causes of tau hyperphosphorylation, brain insulin resistance has generated much attention, and inositols as insulin sensitizers, are currently considered candidates for drug development. The present narrative review revises the interactions between these three elements: Alzheimer's disease-tau-inositols, which can eventually identify targets for new disease modifiers capable of bringing hope to the millions of people affected by this devastating disease. © 2024 Wolters Kluwer Medknow Publications. All rights reserved. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-ShareAlike 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/us/ | * |
| dc.subject.en | Alzheimer’s disease | |
| dc.subject.en | D-Pinitol | |
| dc.subject.en | PI3K/Akt | |
| dc.subject.en | Cyclin-dependent kinase 5 | |
| dc.subject.en | Diabetes | |
| dc.subject.en | Inositols | |
| dc.subject.en | Insulin resistance | |
| dc.subject.en | Kinases | |
| dc.subject.en | Phosphorylation | |
| dc.subject.en | Tau | |
| dc.title.en | Novel insights into D-Pinitol based therapies: A link between tau hyperphosphorylation and insulin resistance | |
| dc.title.alternative | Neural Regen Res | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.4103/1673-5374.379015 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 37488880 | en_US |
| bordeaux.journal | Neural Regeneration Research | en_US |
| bordeaux.page | 289 – 295 | en_US |
| bordeaux.volume | 19 | en_US |
| bordeaux.hal.laboratories | Neurocentre Magendie - U1215 | en_US |
| bordeaux.issue | 2 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | Physiopathologie de l'équilibre énergétique et obésité | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-05073783 | |
| hal.version | 1 | |
| hal.date.transferred | 2025-05-19T13:43:05Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| dc.rights.cc | CC BY-NC-SA | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neural%20Regeneration%20Research&rft.date=2024-02&rft.volume=19&rft.issue=2&rft.spage=289%20%E2%80%93%20295&rft.epage=289%20%E2%80%93%20295&rft.eissn=1673-5374&rft.issn=1673-5374&rft.au=MEDINA-VERA,%20Dina&L%C3%93PEZ-GAMBERO,%20Antonio%20Jes%C3%BAs&NAVARRO,%20Juan%20Antonio&SANJUAN,%20Carlos&BAIXERAS,%20Elena&rft.genre=article |