Morphology of poly(ethylene oxide)-block-polycaprolatone block copolymer micelles controlled via the preparation method
BORSALI, Redouane
Laboratoire de Chimie des polymères organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering
Laboratoire de Chimie des polymères organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering
BORSALI, Redouane
Laboratoire de Chimie des polymères organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering
< Reduce
Laboratoire de Chimie des polymères organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering
Language
en
Article de revue
This item was published in
Macromolecular Symposia. 2006, vol. 245, p. 147-153
Wiley-VCH Verlag
English Abstract
Biocompatible poly(ethylene oxide)-b-polycaprolatone (PEO-b-PCL) micelles have been successfully tested in many fields as nano-carries, especially in drug delivery. We demonstrate herein that using indirect dissolution ...Read more >
Biocompatible poly(ethylene oxide)-b-polycaprolatone (PEO-b-PCL) micelles have been successfully tested in many fields as nano-carries, especially in drug delivery. We demonstrate herein that using indirect dissolution methods to prepare PEO-b-PCL nano-objects in water, copolymers with volume fractions of PCL (phi(PCL)) ranging from 0.35 to 0.58 self-assemble into spherical micelles when either DMF or THF is used as organic solvent to dissolve the diblocks before the micellization. Striking different, regular wormlike morphologies are however obtained using acetone as solvent for copolymers with phi(PCL) = 0.50-0.58. These results emphasize, therefore, that control over the shape of PEO-b-PCL micelles can be achieved not only by precise macromolecular engineering but also through clever processing strategies.Read less <
English Keywords
self-assembly
morphology
poly(ethylene oxide)-b-polycaprolatone
block copolymers
micelles
Origin
Hal imported