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Targeting of Antifungal Metabolites from Grapevine Byproducts by UPLC–HRMS/MS Approaches Using Bioactivity-Based Molecular Networking

dc.rights.licenseopenen_US
hal.structure.identifierUnité de Recherche Œnologie [Villenave d'Ornon] [OENO]
dc.contributor.authorTARDIF, Charles
hal.structure.identifierUnité de Recherche Œnologie [Villenave d'Ornon] [OENO]
dc.contributor.authorROUGER, Caroline
IDREF: 158011724
hal.structure.identifierUnité de Recherche Œnologie [Villenave d'Ornon] [OENO]
dc.contributor.authorMIRANDA, Julie
hal.structure.identifierUnité de Recherche Œnologie [Villenave d'Ornon] [OENO]
dc.contributor.authorAHMED, Omar S.
dc.contributor.authorRICHARD-FORGET, Florence
dc.contributor.authorATANASOVA, Vessela
hal.structure.identifierUnité de Recherche Œnologie [Villenave d'Ornon] [OENO]
dc.contributor.authorWAFFO-TEGUO, Pierre
dc.date.accessioned2025-04-17T09:08:57Z
dc.date.available2025-04-17T09:08:57Z
dc.date.issued2024-04-22
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/206238
dc.description.abstractEnThis study focuses on countering Fusarium graminearum, a harmful fungal pathogen impacting cereal crops and human health through mycotoxin production. These mycotoxins, categorized as type B trichothecenes, pose significant health risks. Research explores natural alternatives to synthetic fungicides, particularly investigating phenolics in grapevine byproducts. Thirteen eco-extracts from five French grape varieties (Merlot, Cabernet Sauvignon, Sauvignon blanc, Tannat, and Artaban) exhibited substantial antifungal properties, with ten extracts displaying remarkable effects. Extracts from grapevine stems and roots notably reduced fungal growth by over 91% after five days. Through UHPLC-HRMS/MS analysis and metabolomics, the study identified potent antifungal compounds such as ampelopsin A and cyphostemmin B, among other oligomeric stilbenes. Interestingly, this approach showed that flavan-3-ols have been identified as markers for extracts that induce fungal growth. Root extracts from rootstocks, rich in oligostilbenes, demonstrated the highest antifungal activity. This research underscores grapevine byproducts’ potential both as a sustainable approach to control F. graminearum and mycotoxin contamination in cereal crops and the presence of different metabolites from the cultivars of grapevine, suggesting different activities. © 2024 American Chemical Society.
dc.description.sponsorshipLes stilbénoïdes: produits naturels prometteurs, respectueux de l'environnement, destinés à réduire la contamination du blé et du raisin par les champignons toxinogènes et les mycotoxines associées - ANR-19-CE21-0007en_US
dc.description.sponsorshipDéveloppement d'une infrastructure française distribuée pour la métabolomique dédiée à l'innovation - ANR-11-INBS-0010en_US
dc.description.sponsorshipCentre français de phénomique végétale - ANR-11-INBS-0012en_US
dc.language.isoENen_US
dc.subject.enVitis vinifera
dc.subject.enByproducts
dc.subject.enStilbenes
dc.subject.enMS/MS-based untargeted metabolomics
dc.subject.enFusarium graminearum
dc.subject.enAntifungal activity
dc.title.enTargeting of Antifungal Metabolites from Grapevine Byproducts by UPLC–HRMS/MS Approaches Using Bioactivity-Based Molecular Networking
dc.typeArticle de revueen_US
dc.identifier.doi10.1021/acs.jafc.3c09531en_US
dc.subject.halSciences du Vivant [q-bio]/Biologie végétaleen_US
bordeaux.journalJournal of Agricultural and Food Chemistryen_US
bordeaux.page9621-9636en_US
bordeaux.volume72en_US
bordeaux.hal.laboratoriesOenologie - UMR 1366en_US
bordeaux.issue17en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Agricultural%20and%20Food%20Chemistry&rft.date=2024-04-22&rft.volume=72&rft.issue=17&rft.spage=9621-9636&rft.epage=9621-9636&rft.au=TARDIF,%20Charles&ROUGER,%20Caroline&MIRANDA,%20Julie&AHMED,%20Omar%20S.&RICHARD-FORGET,%20Florence&rft.genre=article


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