GUIRANDY, Noemie; SIMON, Olivier; GEFFROY, Benjamin; DAFFE, Guillemine; DARAMY, Flore; HOUDELET, Camille; GONZALEZ, Patrice; PIERRON, Fabien

doi:10.1016/j.ecoenv.2023.115790

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GUIRANDY, Noemie
Laboratoire d'écologie et d'écotoxicologie des radionucléides [IRSN/PSE-ENV/SERPEN/LECO]

SIMON, Olivier
Laboratoire d'écologie et d'écotoxicologie des radionucléides [IRSN/PSE-ENV/SERPEN/LECO]

GEFFROY, Benjamin
MARine Biodiversity Exploitation and Conservation - MARBEC [UMR MARBEC]

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Article de revue

Ce document a été publié dans

Ecotoxicology and Environmental Safety. 2024-01, vol. 269, p. 115790

Résumé en anglais

Sex ratio variation is a key topic in ecology, because of its direct effects on population dynamics and thus, on animal conservation strategies. Among factors affecting sex ratio, types of sex determination systems have a central role, since some species could have a sex determined by genetic factors, environmental factors or a mix of those two. Yet, most studies on the factors affecting sex determination have focused on temperature or endocrinedisrupting chemicals (EDCs), and much less is known regarding other factors. Exposure to gamma irradiation was found to trigger offspring masculinization in zebrafish. Here we aimed at deciphering the potential mechanisms involved, by focusing on stress (i.e. cortisol) and epigenetic regulation of key genes involved in sex differentiation in fish. Cortisol levels in exposed and control (F0) zebrafish females' gonads were similar. However, irradiation increased the DNA methylation level of foxl2a and cyp19a1a in females of the F0 and F1 generation, respectively, while no effects were detected in testis. Overall, our results suggest that parental exposure could alter offspring sex ratio, at least in part by inducing methylation changes in ovaries.< Réduire

Mots clés en anglais

Sex differentiation

Methylation

Cortisol

Zebrafish

Irradiation

Multigenerational

URI

https://oskar-bordeaux.fr/handle/20.500.12278/205804

DOI

http://dx.doi.org/10.1016/j.ecoenv.2023.115790

Project ANR

Effets transgénérationnels des polluants chez les poissons: l'épigénétique et son implication en écotoxicologie - ANR-16-CE34-0008

Unités de recherche

EPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805