Gamma irradiation-induced offspring masculinization is associated with epigenetic changes in female zebrafish
GUIRANDY, Noemie
Laboratoire d'écologie et d'écotoxicologie des radionucléides [IRSN/PSE-ENV/SERPEN/LECO]
Laboratoire d'écologie et d'écotoxicologie des radionucléides [IRSN/PSE-ENV/SERPEN/LECO]
SIMON, Olivier
Laboratoire d'écologie et d'écotoxicologie des radionucléides [IRSN/PSE-ENV/SERPEN/LECO]
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Laboratoire d'écologie et d'écotoxicologie des radionucléides [IRSN/PSE-ENV/SERPEN/LECO]
GUIRANDY, Noemie
Laboratoire d'écologie et d'écotoxicologie des radionucléides [IRSN/PSE-ENV/SERPEN/LECO]
Laboratoire d'écologie et d'écotoxicologie des radionucléides [IRSN/PSE-ENV/SERPEN/LECO]
SIMON, Olivier
Laboratoire d'écologie et d'écotoxicologie des radionucléides [IRSN/PSE-ENV/SERPEN/LECO]
< Reduce
Laboratoire d'écologie et d'écotoxicologie des radionucléides [IRSN/PSE-ENV/SERPEN/LECO]
Language
EN
Article de revue
This item was published in
Ecotoxicology and Environmental Safety. 2024-01, vol. 269, p. 115790
English Abstract
Sex ratio variation is a key topic in ecology, because of its direct effects on population dynamics and thus, on animal conservation strategies. Among factors affecting sex ratio, types of sex determination systems have a ...Read more >
Sex ratio variation is a key topic in ecology, because of its direct effects on population dynamics and thus, on animal conservation strategies. Among factors affecting sex ratio, types of sex determination systems have a central role, since some species could have a sex determined by genetic factors, environmental factors or a mix of those two. Yet, most studies on the factors affecting sex determination have focused on temperature or endocrinedisrupting chemicals (EDCs), and much less is known regarding other factors. Exposure to gamma irradiation was found to trigger offspring masculinization in zebrafish. Here we aimed at deciphering the potential mechanisms involved, by focusing on stress (i.e. cortisol) and epigenetic regulation of key genes involved in sex differentiation in fish. Cortisol levels in exposed and control (F0) zebrafish females' gonads were similar. However, irradiation increased the DNA methylation level of foxl2a and cyp19a1a in females of the F0 and F1 generation, respectively, while no effects were detected in testis. Overall, our results suggest that parental exposure could alter offspring sex ratio, at least in part by inducing methylation changes in ovaries.Read less <
English Keywords
Sex differentiation
Methylation
Cortisol
Zebrafish
Irradiation
Multigenerational
ANR Project
Effets transgénérationnels des polluants chez les poissons: l'épigénétique et son implication en écotoxicologie - ANR-16-CE34-0008