LEON, Stéphane; SIMON, Vincent; LEE, Thomas; STEUERNAGEL, Lukas; CLARK, Samantha; BIGLARI, Nasim; LESTÉ-LASSERRE, Thierry; DUPUY, Nathalie; CANNICH, Astrid; BELLOCCHIO, Luigi; ZIZZARI, Philippe; ALLARD, Camille; GONZALES, Delphine; LE FEUVRE, Yves; LHUILLIER, Emeline; BROCHARD, Alexandre; NICOLAS, Jean Charles; TEILLON, Jérémie; NIKOLSKI, Macha; MARSICANO, Giovanni; FIORAMONTI, Xavier; BRÜNING, Jens; COTA, Daniela; QUARTA, Carmelo

doi:10.1038/s41467-024-47877-2

LEON, Stéphane
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

SIMON, Vincent
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

LEE, Thomas
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

Langue

Article de revue

Ce document a été publié dans

Nature Communications. 2024-04, vol. 15, n° 1, p. 3443

Résumé en anglais

The hypothalamus contains a remarkable diversity of neurons that orchestrate behavioural and metabolic outputs in a highly plastic manner. Neuronal diversity is key to enabling hypothalamic functions and, according to the neuroscience dogma, it is predetermined during embryonic life. Here, by combining lineage tracing of hypothalamic pro-opiomelanocortin (Pomc) neurons with single-cell profiling approaches in adult male mice, we uncovered subpopulations of ‘Ghost’ neurons endowed with atypical molecular and functional identity. Compared to ‘classical’ Pomc neurons, Ghost neurons exhibit negligible Pomc expression and are ‘invisible’ to available neuroanatomical approaches and promoter-based reporter mice for studying Pomc biology. Ghost neuron numbers augment in diet-induced obese mice, independent of neurogenesis or cell death, but weight loss can reverse this shift. Our work challenges the notion of fixed, developmentally programmed neuronal identities in the mature hypothalamus and highlight the ability of specialised neurons to reversibly adapt their functional identity to adult-onset obesogenic stimuli.< Réduire

URI

https://oskar-bordeaux.fr/handle/20.500.12278/205566

DOI

http://dx.doi.org/10.1038/s41467-024-47877-2

Voir/Ouvrir

Métadonnées

Licence d’utilisation du document

Single cell tracing of Pomc neurons reveals recruitment of ‘Ghost' subtypes with atypical identity in a mouse model of obesity

Langue

Ce document a été publié dans

Résumé en anglais

URI

DOI

Unités de recherche

Voir/Ouvrir

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Single cell tracing of Pomc neurons reveals recruitment of ‘Ghost' subtypes with atypical identity in a mouse model of obesity

Langue

Ce document a été publié dans

Résumé en anglais

URI

DOI

Unités de recherche