MOUGIN, Camille; CHATAIGNER, Mathilde; LUCAS, Céline; PALLET, Véronique; BOUVRET, Elodie; JOFFRE, Corinne; DINEL, Anne-Laure

doi:10.1371/journal.pone.0309542

MOUGIN, Camille
Nutrition et Neurobiologie intégrée [NutriNeuro]

CHATAIGNER, Mathilde
Nutrition et Neurobiologie intégrée [NutriNeuro]

LUCAS, Céline

Langue

Article de revue

Ce document a été publié dans

PLoS ONE. 2024-10, vol. 19, n° 10, p. e0309542

Résumé en anglais

Aging represents a natural and unavoidable phenomenon in organisms. With the acceleration of population aging, investigations into aging have garnered widespread global interest. One of the most striking aspects of human aging is the decline in brain function, a phenomenon intricately tied to the onset of neurodegenerative conditions. This study aimed to assess the impact of a fish hydrolysate, rich in low-molecular-weight peptides and n-3 LC-PUFAs, on cognitive function, inflammatory response, and oxidative stress via the AGE-RAGE axis in a mouse model of accelerated aging. This model induces cognitive decline and biochemical alterations akin to those observed during natural aging. The findings revealed that fish hydrolysate exhibited a protective effect against cognitive impairment induced by D-galactose. This effect was associated with increased protein expression of SOD1 and decreased genetic expression of IL-6 and advanced glycation end products (AGE). Consequently, within the realm of preventive and personalized nutrition, fish hydrolysate emerges as a promising avenue for mitigating age-related declines in memory function.< Réduire

URI

https://oskar-bordeaux.fr/handle/20.500.12278/205494

DOI

http://dx.doi.org/10.1371/journal.pone.0309542

Unités de recherche

NutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286

Voir/Ouvrir

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Dietary marine hydrolysate alleviates D-galactose-induced brain aging by attenuating cognitive alterations, oxidative stress and inflammation through the AGE-RAGE axis

Langue

Ce document a été publié dans

Résumé en anglais

URI

DOI

Unités de recherche