BLANC-LEGENDRE, M; GUILLOT, L; CHEVALIER, L; MALLERET, C; LE MENACH, Karyn; PARDON, Patrick; BUDZINSKI, Hélène; BRION, F; SIRE, S; COUMAILLEAU, P; CHARLIER, T D; PELLEGRINI, E; COUSIN, X

doi:10.1016/j.etap.2024.104592

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Environmental Toxicology and Pharmacology. 2025-01-01, vol. 113, p. 104592

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Estrogen receptors (ER) are widely expressed in the brain of many species and experimental results highlighted the role of estradiol in neuronal plasticity and behavior. Consequently, the brain is therefore a prime target for endocrine disrupting chemicals (EDCs) interacting with estrogen signaling. Very little is known about the late effects of early disruption of estrogen signaling by EDCs. We focused on: ethinylestradiol (EE2; ER agonist) and clotrimazole (inhibitor of key steroidogenesis enzymes, including aromatases). Zebrafish eleutheroembryos were exposed (0-5 days) and then raised normally until adulthood. Several behavioral tests were performed in adults, then cell proliferation and dopaminergic neurons were quantified in several brain regions using immunostaining. Overall, a developmental exposure to EDCs stimulates cell proliferation in the dorsal telencephalon. At environmentally-relevant concentrations, male fish exposed to EE2 exhibited increased activity levels and decreased social behavior, posing a potential risk to population balance and health.< Leer menos

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Animals

Zebrafish

Ethinyl Estradiol

Clotrimazole

Neuronal Plasticity

Behavior

Animal

Male

Endocrine Disruptors

Embryo

Nonmammalian

Water Pollutants

Chemical

Brain

Female

Cell Proliferation

Dopaminergic Neurons

Social Behavior

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Long-term impact of embryonic exposure to ethinylestradiol and clotrimazole on behavior and neuroplasticity in zebrafish (Danio rerio)

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