Long-term impact of embryonic exposure to ethinylestradiol and clotrimazole on behavior and neuroplasticity in zebrafish (Danio rerio)
| dc.rights.license | open | en_US |
| dc.contributor.author | BLANC-LEGENDRE, M | |
| dc.contributor.author | GUILLOT, L | |
| dc.contributor.author | CHEVALIER, L | |
| dc.contributor.author | MALLERET, C | |
| hal.structure.identifier | Environnements et Paléoenvironnements OCéaniques [EPOC] | |
| dc.contributor.author | LE MENACH, Karyn
IDREF: 256879966 | |
| hal.structure.identifier | Environnements et Paléoenvironnements OCéaniques [EPOC] | |
| dc.contributor.author | PARDON, Patrick | |
| hal.structure.identifier | Environnements et Paléoenvironnements OCéaniques [EPOC] | |
| dc.contributor.author | BUDZINSKI, Hélène | |
| dc.contributor.author | BRION, F | |
| dc.contributor.author | SIRE, S | |
| dc.contributor.author | COUMAILLEAU, P | |
| dc.contributor.author | CHARLIER, T D | |
| dc.contributor.author | PELLEGRINI, E | |
| dc.contributor.author | COUSIN, X | |
| dc.date.accessioned | 2025-02-14T10:39:10Z | |
| dc.date.available | 2025-02-14T10:39:10Z | |
| dc.date.issued | 2025-01-01 | |
| dc.identifier.issn | 1872-7077 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/204888 | |
| dc.description.abstractEn | Estrogen receptors (ER) are widely expressed in the brain of many species and experimental results highlighted the role of estradiol in neuronal plasticity and behavior. Consequently, the brain is therefore a prime target for endocrine disrupting chemicals (EDCs) interacting with estrogen signaling. Very little is known about the late effects of early disruption of estrogen signaling by EDCs. We focused on: ethinylestradiol (EE2; ER agonist) and clotrimazole (inhibitor of key steroidogenesis enzymes, including aromatases). Zebrafish eleutheroembryos were exposed (0-5 days) and then raised normally until adulthood. Several behavioral tests were performed in adults, then cell proliferation and dopaminergic neurons were quantified in several brain regions using immunostaining. Overall, a developmental exposure to EDCs stimulates cell proliferation in the dorsal telencephalon. At environmentally-relevant concentrations, male fish exposed to EE2 exhibited increased activity levels and decreased social behavior, posing a potential risk to population balance and health. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Animals | |
| dc.subject.en | Zebrafish | |
| dc.subject.en | Ethinyl Estradiol | |
| dc.subject.en | Clotrimazole | |
| dc.subject.en | Neuronal Plasticity | |
| dc.subject.en | Behavior | |
| dc.subject.en | Animal | |
| dc.subject.en | Male | |
| dc.subject.en | Endocrine Disruptors | |
| dc.subject.en | Embryo | |
| dc.subject.en | Nonmammalian | |
| dc.subject.en | Water Pollutants | |
| dc.subject.en | Chemical | |
| dc.subject.en | Brain | |
| dc.subject.en | Female | |
| dc.subject.en | Cell Proliferation | |
| dc.subject.en | Dopaminergic Neurons | |
| dc.subject.en | Social Behavior | |
| dc.title.en | Long-term impact of embryonic exposure to ethinylestradiol and clotrimazole on behavior and neuroplasticity in zebrafish (Danio rerio) | |
| dc.title.alternative | Environ Toxicol Pharmacol | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.etap.2024.104592 | en_US |
| dc.subject.hal | Sciences de l'environnement | en_US |
| dc.identifier.pubmed | 39581484 | en_US |
| bordeaux.journal | Environmental Toxicology and Pharmacology | en_US |
| bordeaux.page | 104592 | en_US |
| bordeaux.volume | 113 | en_US |
| bordeaux.hal.laboratories | EPOC | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.team | LPTC | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Environmental%20Toxicology%20and%20Pharmacology&rft.date=2025-01-01&rft.volume=113&rft.spage=104592&rft.epage=104592&rft.eissn=1872-7077&rft.issn=1872-7077&rft.au=BLANC-LEGENDRE,%20M&GUILLOT,%20L&CHEVALIER,%20L&MALLERET,%20C&LE%20MENACH,%20Karyn&rft.genre=article |
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