Biologically Active Polymersomes from Amphiphilic Glycopeptides
LECOMMANDOUX, Sebastien
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
< Reduce
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Language
en
Article de revue
This item was published in
Journal of the American Chemical Society. 2012, vol. 134, n° 1, p. 119-122
American Chemical Society
English Abstract
Polypeptide block copolymers with different block length ratios were obtained by sequential ring-opening polymerization of benzyl-L-glutamate and propargylglycine (PG) N-carboxyanhydrides. Glycosylation of the poly(PG) ...Read more >
Polypeptide block copolymers with different block length ratios were obtained by sequential ring-opening polymerization of benzyl-L-glutamate and propargylglycine (PG) N-carboxyanhydrides. Glycosylation of the poly(PG) block was obtained by Huisgens cycloaddition "click" reaction using azide-functionalized galactose. All copolymers were self-assembled using the nanoprecipitation method to obtain spherical and wormlike micelles as well as polymersomes depending on the block length ratio and the nanoprecipitation conditions. These structures display bioactive galactose units in the polymersome shell, as proven by selective lectin binding experiments.Read less <
English Keywords
DRUG-DELIVERY
RECOGNITION PROPERTIES
MULTIPLE MORPHOLOGIES
COPOLYMER VESICLES
BLOCK-COPOLYMERS
GENE DELIVERY
BINDING
GLYCOPROTEIN
THERAPEUTICS
LACTOSE
Origin
Hal imported