Improved size-tunable preparation of polymeric nanoparticles by microfluidic nanoprecipitation
VANDAMME, Thierry
Institut de Mécanique des Fluides et des Solides [IMFS]
Conception et application de molécules bioactives [CAMB]
Institut de Mécanique des Fluides et des Solides [IMFS]
Conception et application de molécules bioactives [CAMB]
HADZIIOANNOU, Georges
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 4 LCPO : Polymer Materials for Electronic, Energy, Information and Communication Technologies
< Réduire
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 4 LCPO : Polymer Materials for Electronic, Energy, Information and Communication Technologies
Langue
en
Article de revue
Ce document a été publié dans
Polymer. 2012, vol. 53, n° 22, p. 5045-5051
Elsevier
Résumé en anglais
Size-tunable polymeric nanoparticles have been successfully produced by a microfluidic-assisted nanoprecipitation process. A multilamination micromixer has been chosen to fabricate continuously nanoparticles of methacrylic ...Lire la suite >
Size-tunable polymeric nanoparticles have been successfully produced by a microfluidic-assisted nanoprecipitation process. A multilamination micromixer has been chosen to fabricate continuously nanoparticles of methacrylic polymers. Various operating conditions, such as the polymer concentration, the amount of non-solvent and the characteristics of the raw polymer (molecular weight and architecture: linear vs. branched) have been investigated. Their influences on the final particle size, ranging from 76 to 217 nm, have been correlated to the mechanisms leading to the formation of nanoparticles. In this type of microfluidic device, mixing mainly operates by diffusion mass transfer, helped by hydrodynamic focusing. The effect of micromixing on the size of particles has also been shown experimentally and supported by a computational fluid dynamics (CFD) study. A mixing criterion has been defined and numerically calculated to corroborate the effect of the flow rate of polymer solution on the particles size. An increase in the polymer solution flow rate increases the value of this mixing criterion, resulting in smaller nanoparticles.< Réduire
Mots clés en italien
Polymeric nanoparticle
Nanoprecipitation
Microprocess
CFD numerical simulation
Origine
Importé de halUnités de recherche