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Improved size-tunable preparation of polymeric nanoparticles by microfluidic nanoprecipitation

dc.rights.licenseopen
hal.structure.identifierEcole nationale supérieure de chimie, polymères et materiaux de strasbourg (ECPM)
dc.contributor.authorBALLY, Florence
hal.structure.identifierInstitut de Mécanique des Fluides et des Solides [IMFS]
dc.contributor.authorGARG, Dhiraj Kumar
hal.structure.identifierEcole nationale supérieure de chimie, polymères et materiaux de strasbourg (ECPM)
dc.contributor.authorSERRA, Christophe A.
hal.structure.identifierInstitut de Mécanique des Fluides et des Solides [IMFS]
dc.contributor.authorHOARAU, Yannick
hal.structure.identifierConception et application de molécules bioactives [CAMB]
dc.contributor.authorANTON, Nicolas
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorBROCHON, Cyril
hal.structure.identifierEcole nationale supérieure de chimie, polymères et materiaux de strasbourg (ECPM)
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorPARIDA, Dambarudhar
hal.structure.identifierInstitut de Mécanique des Fluides et des Solides [IMFS]
hal.structure.identifierConception et application de molécules bioactives [CAMB]
dc.contributor.authorVANDAMME, Thierry
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 4 LCPO : Polymer Materials for Electronic, Energy, Information and Communication Technologies
dc.contributor.authorHADZIIOANNOU, Georges
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2012
dc.identifier.issn0032-3861
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/20457
dc.description.abstractEnSize-tunable polymeric nanoparticles have been successfully produced by a microfluidic-assisted nanoprecipitation process. A multilamination micromixer has been chosen to fabricate continuously nanoparticles of methacrylic polymers. Various operating conditions, such as the polymer concentration, the amount of non-solvent and the characteristics of the raw polymer (molecular weight and architecture: linear vs. branched) have been investigated. Their influences on the final particle size, ranging from 76 to 217 nm, have been correlated to the mechanisms leading to the formation of nanoparticles. In this type of microfluidic device, mixing mainly operates by diffusion mass transfer, helped by hydrodynamic focusing. The effect of micromixing on the size of particles has also been shown experimentally and supported by a computational fluid dynamics (CFD) study. A mixing criterion has been defined and numerically calculated to corroborate the effect of the flow rate of polymer solution on the particles size. An increase in the polymer solution flow rate increases the value of this mixing criterion, resulting in smaller nanoparticles.
dc.language.isoen
dc.publisherElsevier
dc.title.enImproved size-tunable preparation of polymeric nanoparticles by microfluidic nanoprecipitation
dc.typeArticle de revue
dc.identifier.doi10.1016/j.polymer.2012.08.039
dc.subject.halChimie/Polymères
bordeaux.journalPolymer
bordeaux.page5045-5051
bordeaux.volume53
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue22
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-00803377
hal.version1
dc.subject.itPolymeric nanoparticle
dc.subject.itNanoprecipitation
dc.subject.itMicroprocess
dc.subject.itCFD numerical simulation
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00803377v1
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