BOSCHER, Flore; JUMEL, Katlyn; DVORKOV, Tereza; GENTET, Luc J; URBAIN, Nadia

doi:10.1523/jneurosci.0158-24.2024

JUMEL, Katlyn
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]

DVORKOV, Tereza

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Article de revue

Ce document a été publié dans

Journal of Neuroscience. 2024-06-19, vol. 44, n° 25, p. e0158242024

Résumé en anglais

Rapid eye movement (REM) sleep, also referred to as paradoxical sleep for the striking resemblance of its electroencephalogram (EEG) to the one observed in wakefulness, is characterized by the occurrence of transient events such as limb twitches or facial and rapid eye movements. Here, we investigated the local activity of the primary somatosensory or barrel cortex (S1) in naturally sleeping head-fixed male mice during REM. Through local field potential recordings, we uncovered local appearances of spindle waves in the barrel cortex during REM concomitant with strong delta power, challenging the view of a wakefulness-like activity in REM. We further performed extra- and intracellular recordings of thalamic cells in head-fixed mice. Our data show high-frequency thalamic bursts of spikes and subthreshold spindle oscillations in approximately half of the neurons of the ventral posterior medial nucleus which further confirmed the thalamic origin of local cortical spindles in S1 in REM. Cortical spindle oscillations were suppressed, while thalamus spike firing increased, associated with rapid mouse whisker movements and S1 cortical activity transitioned to an activated state. During REM, the sensory thalamus and barrel cortex therefore alternate between high (wake-like) and low (non-REM sleep-like) activation states, potentially providing a neuronal substrate for mnemonic processes occurring during this paradoxical sleep stage.< Réduire

Mots clés en anglais

REM sleep

Spindle

Whisking

Somatosensory

Thalamus

Barrel cortex

Electrophysiology

Single-unit recordings

Local field potential

URI

https://oskar-bordeaux.fr/handle/20.500.12278/204417

DOI

http://dx.doi.org/10.1523/jneurosci.0158-24.2024

Project ANR

Le sommeil paradoxical décodé - ANR-17-CE16-0024
Integration et filtrage de l'information dans le thalamus sensoriel d'ordre élevé - ANR-21-CE16-0017

Unités de recherche

CBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248

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Thalamocortical Dynamics during Rapid Eye Movement Sleep in the Mouse Somatosensory Pathway