KRASTEVA, Petya V

doi:10.1016/j.mib.2024.102476

KRASTEVA, Petya V
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]

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Article de revue

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Current Opinion in Microbiology. 2024-04-29, vol. 79, p. 102476

Resumen en inglés

Bacterial biofilms are a prevalent multicellular life form in which individual members can undergo significant functional differentiation and are typically embedded in a complex extracellular matrix of proteinaceous fimbriae, extracellular DNA, and exopolysaccharides (EPS). Bacteria have evolved at least four major mechanisms for EPS biosynthesis, of which the synthase-dependent systems for bacterial cellulose secretion (Bcs) represent not only key biofilm determinants in a wide array of environmental and host-associated microbes, but also an important model system for the studies of processive glycan polymerization, cyclic diguanylate (c-di-GMP)-dependent synthase regulation, and biotechnological polymer applications. The secreted cellulosic chains can be decorated with additional chemical groups or can pack with various degrees of crystallinity depending on dedicated enzymatic complexes and/ or cytoskeletal scaffolds. Here, I review recent progress in our understanding of synthase-dependent EPS biogenesis with a focus on common and idiosyncratic molecular mechanisms across diverse cellulose secretion systems.< Leer menos

Palabras clave en inglés

Bacterial biofilms

C-di-GMP signaling

EPS

Matrix exopolysaccharides

Synthase-dependent systems

URI

https://oskar-bordeaux.fr/handle/20.500.12278/204407

DOI

http://dx.doi.org/10.1016/j.mib.2024.102476

Proyecto ANR

Mécanismes de la Sécrétion de Cellulose Bactérienne dans les Interactions avec les Plantes Hôtes - ANR-23-CE11-0015
Glycoprotéines et entrée dans les cellules hôtes – Structure et fonction du mécanisme de fusion KSHV - ANR-23-CE11-0032

Centros de investigación

CBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248

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Bacterial synthase-dependent exopolysaccharide secretion: a focus on cellulose