PSIMADAS, Dimitrios; DE OLIVEIRA, Hugo; THEVENOT, Julie; LECOMMANDOUX, Sebastien; BOUZIOTIS, Penelope; VARVARIGOU, Alexandra D.; GEORGOULIAS, Panagiotis; LOUDOS, George

doi:10.3109/10837450.2013.763264

Métadonnées

Licence d’utilisation du document

PSIMADAS, Dimitrios
Technol Educ Inst Athens
National Center for Scientific Research "Demokritos" [NCSR]
Univ Hosp Larissa

DE OLIVEIRA, Hugo
Laboratoire de Chimie des Polymères Organiques [LCPO]

THEVENOT, Julie
Laboratoire de Chimie des Polymères Organiques [LCPO]

Langue

Article de revue

Ce document a été publié dans

Pharmaceutical Development and Technology. 2014, vol. 19, n° 2, p. 189-193

Taylor & Francis

Résumé en anglais

The application of combined diagnosis and therapy through nanotechnology applications is attracting increasing attention worldwide. Polymeric self-assembled nanoparticles (NPs) have been studied for this purpose. Micelles and vesicles with or without a magnetic core can efficiently carry diagnostic and/or therapeutic agents to a desired target. The biological behavior of these NPs has been evaluated in this study, after radiolabeling with Tc-99m. In vitro stability, in media that mimic the environment of the living body, was better for vesicles than for micelles at 1 h and decreased for both as time passed. After administration to healthy animals, all NPs presented major uptake at liver and spleen as expected. Biodistribution and imaging studies confirmed the higher uptake in these organs for the hybrid NPs and at higher extent for the ones with larger size, indicating that the magnetic load and size play an important role on in vivo distribution.< Réduire

Mots clés en anglais

Biodistribution

imaging

nanoparticles

technetium

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Polymeric micelles and vesicles: biological behavior evaluation using radiolabeling techniques

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

DOI

Origine

Unités de recherche