Polymeric micelles and vesicles: biological behavior evaluation using radiolabeling techniques
PSIMADAS, Dimitrios
Technol Educ Inst Athens
National Center for Scientific Research "Demokritos" [NCSR]
Univ Hosp Larissa
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Technol Educ Inst Athens
National Center for Scientific Research "Demokritos" [NCSR]
Univ Hosp Larissa
PSIMADAS, Dimitrios
Technol Educ Inst Athens
National Center for Scientific Research "Demokritos" [NCSR]
Univ Hosp Larissa
Technol Educ Inst Athens
National Center for Scientific Research "Demokritos" [NCSR]
Univ Hosp Larissa
LECOMMANDOUX, Sebastien
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
< Leer menos
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Idioma
en
Article de revue
Este ítem está publicado en
Pharmaceutical Development and Technology. 2014, vol. 19, n° 2, p. 189-193
Taylor & Francis
Resumen en inglés
The application of combined diagnosis and therapy through nanotechnology applications is attracting increasing attention worldwide. Polymeric self-assembled nanoparticles (NPs) have been studied for this purpose. Micelles ...Leer más >
The application of combined diagnosis and therapy through nanotechnology applications is attracting increasing attention worldwide. Polymeric self-assembled nanoparticles (NPs) have been studied for this purpose. Micelles and vesicles with or without a magnetic core can efficiently carry diagnostic and/or therapeutic agents to a desired target. The biological behavior of these NPs has been evaluated in this study, after radiolabeling with Tc-99m. In vitro stability, in media that mimic the environment of the living body, was better for vesicles than for micelles at 1 h and decreased for both as time passed. After administration to healthy animals, all NPs presented major uptake at liver and spleen as expected. Biodistribution and imaging studies confirmed the higher uptake in these organs for the hybrid NPs and at higher extent for the ones with larger size, indicating that the magnetic load and size play an important role on in vivo distribution.< Leer menos
Palabras clave en inglés
Biodistribution
imaging
nanoparticles
technetium
Orígen
Importado de HalCentros de investigación