PLOURDE, Guillaume; ROUMES, Helene; SUISSA, Laurent; HIRT, Lorenz; DOCHE, Émilie; PELLERIN, Luc; BOUZIER-SORE, Anne-Karine; QUINTARD, Hervé

doi:10.1177/0271678X241245486

ROUMES, Helene
Centre de résonance magnétique des systèmes biologiques [CRMSB]
Nutrition et Neurobiologie intégrée [NutriNeuro]

SUISSA, Laurent

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Ce document a été publié dans

Journal of Cerebral Blood Flow and Metabolism. 2024-04-11, vol. 44, n° 7, p. 1078-1088

Résumé en anglais

The goal of neurocritical care is to prevent and reverse the pathologic cascades of secondary brain injury by optimizing cerebral blood flow, oxygen supply and substrate delivery. While glucose is an essential energetic substrate for the brain, we frequently observe a strong decrease in glucose delivery and/or a glucose metabolic dysregulation following acute brain injury. In parallel, during the last decades, lactate and ketone bodies have been identified as potential alternative fuels to provide energy to the brain, both under physiological conditions and in case of glucose shortage. They are now viewed as integral parts of brain metabolism. In addition to their energetic role, experimental evidence also supports their neuroprotective properties after acute brain injury, regulating in particular intracranial pressure control, decreasing ischemic volume, and leading to an improvement in cognitive functions as well as survival. In this review, we present preclinical and clinical evidence exploring the mechanisms underlying their neuroprotective effects and identify research priorities for promoting lactate and ketone bodies use in brain injury.< Réduire

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https://oskar-bordeaux.fr/handle/20.500.12278/203278

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http://dx.doi.org/10.1177/0271678X241245486

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Centre de Résonance Magnétique des Systèmes Biologiques (CRMSB) - UMR 5536

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Neuroprotective effects of lactate and ketone bodies in acute brain injury

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