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Neuroprotective effects of lactate and ketone bodies in acute brain injury

dc.rights.licenseopenen_US
dc.contributor.authorPLOURDE, Guillaume
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorROUMES, Helene
dc.contributor.authorSUISSA, Laurent
dc.contributor.authorHIRT, Lorenz
dc.contributor.authorDOCHE, Émilie
dc.contributor.authorPELLERIN, Luc
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorBOUZIER-SORE, Anne-Karine
dc.contributor.authorQUINTARD, Hervé
dc.date.accessioned2024-11-14T14:10:02Z
dc.date.available2024-11-14T14:10:02Z
dc.date.issued2024-04-11
dc.identifier.issn0271-678Xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/203278
dc.description.abstractEnThe goal of neurocritical care is to prevent and reverse the pathologic cascades of secondary brain injury by optimizing cerebral blood flow, oxygen supply and substrate delivery. While glucose is an essential energetic substrate for the brain, we frequently observe a strong decrease in glucose delivery and/or a glucose metabolic dysregulation following acute brain injury. In parallel, during the last decades, lactate and ketone bodies have been identified as potential alternative fuels to provide energy to the brain, both under physiological conditions and in case of glucose shortage. They are now viewed as integral parts of brain metabolism. In addition to their energetic role, experimental evidence also supports their neuroprotective properties after acute brain injury, regulating in particular intracranial pressure control, decreasing ischemic volume, and leading to an improvement in cognitive functions as well as survival. In this review, we present preclinical and clinical evidence exploring the mechanisms underlying their neuroprotective effects and identify research priorities for promoting lactate and ketone bodies use in brain injury.
dc.language.isoENen_US
dc.title.enNeuroprotective effects of lactate and ketone bodies in acute brain injury
dc.typeArticle de revueen_US
dc.identifier.doi10.1177/0271678X241245486en_US
dc.subject.halSciences du Vivant [q-bio]en_US
bordeaux.journalJournal of Cerebral Blood Flow and Metabolismen_US
bordeaux.page1078-1088en_US
bordeaux.volume44en_US
bordeaux.hal.laboratoriesCentre de Résonance Magnétique des Systèmes Biologiques (CRMSB) - UMR 5536en_US
bordeaux.issue7en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-04766006
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Cerebral%20Blood%20Flow%20and%20Metabolism&rft.date=2024-04-11&rft.volume=44&rft.issue=7&rft.spage=1078-1088&rft.epage=1078-1088&rft.eissn=0271-678X&rft.issn=0271-678X&rft.au=PLOURDE,%20Guillaume&ROUMES,%20Helene&SUISSA,%20Laurent&HIRT,%20Lorenz&DOCHE,%20%C3%89milie&rft.genre=article


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