BASYUK, Eugenia; RAGE, Florence; BERTRAND, Edouard

doi:10.1080/15476286.2020.1842631

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BASYUK, Eugenia
Microbiologie Fondamentale et Pathogénicité [MFP]

RAGE, Florence

BERTRAND, Edouard

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RNA Biology. 2021-09-01, vol. 18, n° 9, p. 1221-1237

Résumé en anglais

Transport of mRNAs is an important step of gene expression, which brings the genetic message from the DNA in the nucleus to a precise cytoplasmic location in a regulated fashion. Perturbation of this process can lead to pathologies such as developmental and neurological disorders. In this review, we discuss recent advances in the field of mRNA transport made using single molecule fluorescent imaging approaches. We present an overview of these approaches in fixed and live cells and their input in understanding the key steps of mRNA journey: transport across the nucleoplasm, export through the nuclear pores and delivery to its final cytoplasmic location. This review puts a particular emphasis on the coupling of mRNA transport with translation, such as localization-dependent translational regulation and translation-dependent mRNA localization. We also highlight the recently discovered translation factories, and how cellular and viral RNAs can hijack membrane transport systems to travel in the cytoplasm.< Réduire

Mots clés en anglais

Animals

Cell Nucleus

Cytoplasm

Humans

Protein Biosynthesis

RNA Transport

RNA

Messenger

Transcription

Genetic

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RNA transport from transcription to localized translation: a single molecule perspective.

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