LAPORTE, Damien; COURTOUT, Fabien; PINSON, Benoît; DOMPIERRE, Jim; SALIN, Bénédicte; BROCARD, Lysiane; SAGOT, Isabelle

doi:10.1083/jcb.201502025

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LAPORTE, Damien
Institut de biochimie et génétique cellulaires [IBGC]

COURTOUT, Fabien
Institut de biochimie et génétique cellulaires [IBGC]

PINSON, Benoît
Institut de biochimie et génétique cellulaires [IBGC]

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Journal of Cell Biology. 2015-07-06, vol. 210, n° 1, p. 99-113

Rockefeller University Press

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Cells perpetually face the decision to proliferate or to stay quiescent. Here we show that upon quiescence establishment, Schizosaccharomyces pombe cells drastically rearrange both their actin and microtubule (MT) cytoskeletons and lose their polarity. Indeed, while polarity markers are lost from cell extremities, actin patches and cables are reorganized into actin bodies, which are stable actin filament–containing structures. Astonishingly, MTs are also stabilized and rearranged into a novel antiparallel bundle associated with the spindle pole body, named Q-MT bundle. We have identified proteins involved in this process and propose a molecular model for Q-MT bundle formation. Finally and importantly, we reveal that Q-MT bundle elongation is involved in polarity reestablishment upon quiescence exit and thereby the efficient return to the proliferative state. Our work demonstrates that quiescent S. pombe cells assemble specific cytoskeleton structures that improve the swiftness of the transition back to proliferation.< Leer menos

Palabras clave en inglés

benzimidazol-2-yl-carbamate

MPA

mycophenolic acid

microtubule

MTOC

MT organizing center

SPB

benzimidazol-2-yl-carbamate MPA

mycophenolic acid MT

microtubule MTOC

MT organizing center SPB

spindle pole

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A stable microtubule array drives fission yeast polarity reestablishment upon quiescence exit

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