LIAU, Walter T.; BONDUELLE, Colin; BROCHET, Marion; LECOMMANDOUX, Sebastien; KASKO, Andrea M.

doi:10.1021/bm501482q

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LIAU, Walter T.
Univ Calif Los Angeles, Dept Bioengn

BONDUELLE, Colin

Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

BROCHET, Marion
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

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Biomacromolecules. 2015, vol. 16, n° 1, p. 284-294

American Chemical Society

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Branched amphiphilic copolymers were synthesized through the reversible additionfragmentation chain transfer (RAFT) chain extension of a poly(methyl acrylate) macro-chain transfer agent using a protected galactose monomer and a polymerizable chain transfer agent branching unit. After galactose deprotection, the copolymers were self-assembled via nanoprecipitation. The resultant nanoparticles were analyzed for their size, shape, and biological interaction with a galactose binding lectin. Using light scattering, the nanoparticles were determined to be solid spheres. Nanoparticles containing branched glycoblocks bound significantly more lectin than those containing comparable linear blocks. By adjusting the molecular weight and branching of the copolymer, the size of the self-assembled nanoparticle and the saccharide density on its surface can be varied.< Réduire

Mots clés en anglais

POLYMERS

RECOGNITION

POLYSTYRENE

LIVING RADICAL POLYMERIZATION

BLOCK-COPOLYMERS

DIBLOCK GLYCOPOLYMERS

RAFT POLYMERIZATION

BETA-CYCLODEXTRIN

DRUG-DELIVERY

MICELLES

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Synthesis, Characterization, and Biological Interaction of Glyconanoparticles with Controlled Branching

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