Synthesis, Characterization, and Biological Interaction of Glyconanoparticles with Controlled Branching
| dc.rights.license | open | |
| hal.structure.identifier | Univ Calif Los Angeles, Dept Bioengn | |
| dc.contributor.author | LIAU, Walter T. | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
| dc.contributor.author | BONDUELLE, Colin
IDREF: 134527046 | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
| dc.contributor.author | BROCHET, Marion | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
| dc.contributor.author | LECOMMANDOUX, Sebastien | |
| hal.structure.identifier | Univ Calif Los Angeles, Dept Bioengn | |
| dc.contributor.author | KASKO, Andrea M. | |
| dc.date.accessioned | 2020 | |
| dc.date.available | 2020 | |
| dc.date.created | 2015 | |
| dc.date.issued | 2015 | |
| dc.identifier.issn | 1525-7797 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/20262 | |
| dc.description.abstractEn | Branched amphiphilic copolymers were synthesized through the reversible additionfragmentation chain transfer (RAFT) chain extension of a poly(methyl acrylate) macro-chain transfer agent using a protected galactose monomer and a polymerizable chain transfer agent branching unit. After galactose deprotection, the copolymers were self-assembled via nanoprecipitation. The resultant nanoparticles were analyzed for their size, shape, and biological interaction with a galactose binding lectin. Using light scattering, the nanoparticles were determined to be solid spheres. Nanoparticles containing branched glycoblocks bound significantly more lectin than those containing comparable linear blocks. By adjusting the molecular weight and branching of the copolymer, the size of the self-assembled nanoparticle and the saccharide density on its surface can be varied. | |
| dc.language.iso | en | |
| dc.publisher | American Chemical Society | |
| dc.subject.en | POLYMERS | |
| dc.subject.en | RECOGNITION | |
| dc.subject.en | POLYSTYRENE | |
| dc.subject.en | LIVING RADICAL POLYMERIZATION | |
| dc.subject.en | BLOCK-COPOLYMERS | |
| dc.subject.en | DIBLOCK GLYCOPOLYMERS | |
| dc.subject.en | RAFT POLYMERIZATION | |
| dc.subject.en | BETA-CYCLODEXTRIN | |
| dc.subject.en | DRUG-DELIVERY | |
| dc.subject.en | MICELLES | |
| dc.title.en | Synthesis, Characterization, and Biological Interaction of Glyconanoparticles with Controlled Branching | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1021/bm501482q | |
| dc.subject.hal | Chimie/Polymères | |
| bordeaux.journal | Biomacromolecules | |
| bordeaux.page | 284-294 | |
| bordeaux.volume | 16 | |
| bordeaux.hal.laboratories | Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629 | * |
| bordeaux.issue | 1 | |
| bordeaux.institution | Bordeaux INP | |
| bordeaux.institution | Université de Bordeaux | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-01361905 | |
| hal.version | 1 | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-01361905v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biomacromolecules&rft.date=2015&rft.volume=16&rft.issue=1&rft.spage=284-294&rft.epage=284-294&rft.eissn=1525-7797&rft.issn=1525-7797&rft.au=LIAU,%20Walter%20T.&BONDUELLE,%20Colin&BROCHET,%20Marion&LECOMMANDOUX,%20Sebastien&KASKO,%20Andrea%20M.&rft.genre=article |
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