LEGROS, Camille; WIROTIUS, Anne-Laure; DE PAUW-GILLET, Marie-Claire; TAM, Kam Chiu; TATON, Daniel; LECOMMANDOUX, Sebastien

doi:10.1021/bm501393q

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LEGROS, Camille
Laboratoire de Chimie des Polymères Organiques [LCPO]
Institute for Nanotechnology [Waterloo]

WIROTIUS, Anne-Laure
Laboratoire de Chimie des Polymères Organiques [LCPO]

DE PAUW-GILLET, Marie-Claire
Laboratory of Mammalian Cell Culture [GIGA-R]

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Biomacromolecules. 2015, vol. 16, n° 1, p. 183-191

American Chemical Society

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Hydrophilic nanogels based on partially hydrolyzed poly(2-ethyl-2-oxazoline) were synthesized in dilute aqueous media in the presence of 1,6-hexanediol diglycidyl ether as a cross-linker. Nanogel formation was monitored by DLS and HSQC NMR spectroscopy, and the final nano-objects were characterized by DLS, TEM, AFM, and NanoSight analyses. Nanogels with a hydrodynamic radius of 78 nm exhibiting a slight positive surface charge were obtained. MTS assays (cell metabolic activity test) evidenced that nanogels were nontoxic in the investigated concentration range (i.e., 0.1 to 400 mu g/mL) and that no specific interaction with bovine serum albumin was observed.< Leer menos

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BIOMEDICAL APPLICATIONS

BLOCK-COPOLYMERS

AGGREGATION BEHAVIOR

POLY(2-ETHYL-2-OXAZOLINE)

POLY(ETHYLENE GLYCOL)

GENE DELIVERY

IN-VITRO

DRUG-DELIVERY

PROTEIN ADSORPTION

POLYMERIC NANOPARTICLES

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Poly(2-oxazoline)-Based Nanogels as Biocompatible Pseudopolypeptide Nanoparticles

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