Poly(2-oxazoline)-Based Nanogels as Biocompatible Pseudopolypeptide Nanoparticles
LEGROS, Camille
Laboratoire de Chimie des Polymères Organiques [LCPO]
Institute for Nanotechnology [Waterloo]
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Laboratoire de Chimie des Polymères Organiques [LCPO]
Institute for Nanotechnology [Waterloo]
LEGROS, Camille
Laboratoire de Chimie des Polymères Organiques [LCPO]
Institute for Nanotechnology [Waterloo]
Laboratoire de Chimie des Polymères Organiques [LCPO]
Institute for Nanotechnology [Waterloo]
TATON, Daniel
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering
LECOMMANDOUX, Sebastien
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
< Réduire
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Langue
en
Article de revue
Ce document a été publié dans
Biomacromolecules. 2015, vol. 16, n° 1, p. 183-191
American Chemical Society
Résumé en anglais
Hydrophilic nanogels based on partially hydrolyzed poly(2-ethyl-2-oxazoline) were synthesized in dilute aqueous media in the presence of 1,6-hexanediol diglycidyl ether as a cross-linker. Nanogel formation was monitored ...Lire la suite >
Hydrophilic nanogels based on partially hydrolyzed poly(2-ethyl-2-oxazoline) were synthesized in dilute aqueous media in the presence of 1,6-hexanediol diglycidyl ether as a cross-linker. Nanogel formation was monitored by DLS and HSQC NMR spectroscopy, and the final nano-objects were characterized by DLS, TEM, AFM, and NanoSight analyses. Nanogels with a hydrodynamic radius of 78 nm exhibiting a slight positive surface charge were obtained. MTS assays (cell metabolic activity test) evidenced that nanogels were nontoxic in the investigated concentration range (i.e., 0.1 to 400 mu g/mL) and that no specific interaction with bovine serum albumin was observed.< Réduire
Mots clés en anglais
BIOMEDICAL APPLICATIONS
BLOCK-COPOLYMERS
AGGREGATION BEHAVIOR
POLY(2-ETHYL-2-OXAZOLINE)
POLY(ETHYLENE GLYCOL)
GENE DELIVERY
IN-VITRO
DRUG-DELIVERY
PROTEIN ADSORPTION
POLYMERIC NANOPARTICLES
Origine
Importé de halUnités de recherche