The missing link : TBK1 connects membrane damage sensing with autophagic response upon adenovirus entry
| dc.rights.license | open | en_US |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | DAUSSY, Coralie | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | PIED, Noémie | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | RAYNE, Fabienne | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | WODRICH, Harald | |
| dc.date.accessioned | 2024-10-19T08:48:05Z | |
| dc.date.available | 2024-10-19T08:48:05Z | |
| dc.date.issued | 2022-10-25 | |
| dc.identifier.issn | 2769-4127 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/202590 | |
| dc.description.abstractEn | Most cell entry by invading pathogens involves penetration of either the plasma membrane or the endo-lysosomal compartment to reach the cytosol. This process frequently inflicts membrane damage and provokes a cellular response. This Autophagic Punctum summarizes our recent study investigating how adenovirus endosome penetration is recognized and activates macroautophagy/autophagy. Our key finding is that TBK1 (TANK binding kinase 1) has a dual role in the cell response to membrane damage; it is part of an immediateacting membrane-damage-sensing complex and is a crucial driver of the resulting autophagic response. Thus, TBK1 is a central factor linking sensors and effectors during the cell response to membrane damage. | |
| dc.language.iso | EN | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by/ | |
| dc.subject.en | Adenovirus autophagy galectin 8 lysosomal damage membrane damage TBK1 virus entry | |
| dc.subject.en | Adenovirus | |
| dc.subject.en | autophagy | |
| dc.subject.en | galectin 8 | |
| dc.subject.en | lysosomal damage | |
| dc.subject.en | membrane damage | |
| dc.subject.en | TBK1 | |
| dc.subject.en | virus entry | |
| dc.title.en | The missing link : TBK1 connects membrane damage sensing with autophagic response upon adenovirus entry | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1080/27694127.2022.2136604 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio] | en_US |
| bordeaux.journal | Autophagy Reports | en_US |
| bordeaux.page | 551-554 | en_US |
| bordeaux.volume | 1 | en_US |
| bordeaux.hal.laboratories | MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | hal | |
| hal.identifier | hal-04741874 | |
| hal.version | 1 | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| workflow.import.source | hal | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Autophagy%20Reports&rft.date=2022-10-25&rft.volume=1&rft.issue=1&rft.spage=551-554&rft.epage=551-554&rft.eissn=2769-4127&rft.issn=2769-4127&rft.au=DAUSSY,%20Coralie&PIED,%20No%C3%A9mie&RAYNE,%20Fabienne&WODRICH,%20Harald&rft.genre=article |
