DAUSSY, Coralie F; WODRICH, Harald

doi:10.3390/cells9092042

DAUSSY, Coralie F
Microbiologie Fondamentale et Pathogénicité [MFP]

WODRICH, Harald

Microbiologie Fondamentale et Pathogénicité [MFP]

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Article de revue

Ce document a été publié dans

Cells. 2020-09-07, vol. 9, n° 9

Résumé en anglais

Cells are constantly challenged by pathogens (bacteria, virus, and fungi), and protein aggregates or chemicals, which can provoke membrane damage at the plasma membrane or within the endo-lysosomal compartments. Detection of endo-lysosomal rupture depends on a family of sugar-binding lectins, known as galectins, which sense the abnormal exposure of glycans to the cytoplasm upon membrane damage. Galectins in conjunction with other factors orchestrate specific membrane damage responses such as the recruitment of the endosomal sorting complex required for transport (ESCRT) machinery to either repair damaged membranes or the activation of autophagy to remove membrane remnants. If not controlled, membrane damage causes the release of harmful components including protons, reactive oxygen species, or cathepsins that will elicit inflammation. In this review, we provide an overview of current knowledge on membrane damage and cellular responses. In particular, we focus on the endo-lysosomal damage triggered by non-enveloped viruses (such as adenovirus) and discuss viral strategies to control the cellular membrane damage response. Finally, we debate the link between autophagy and inflammation in this context and discuss the possibility that virus induced autophagy upon entry limits inflammation.< Réduire

Mots clés en anglais

Autophagy

Humans

Lysosomes

URI

https://oskar-bordeaux.fr/handle/20.500.12278/202029

DOI

http://dx.doi.org/10.3390/cells9092042

Unités de recherche

MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234

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"Repair Me if You Can": Membrane Damage, Response, and Control from the Viral Perspective.

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Résumé en anglais

Mots clés en anglais

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