GAUTHIER, Yvon; LEPREUX, Sebastien; CARIO-ANDRE, Muriel; RAMBERT, Jérome; DAKDAKI, Adrien; LAFON, Marie-Edith; ABOUQAL, Redouane; BENZEKRI, Laila

doi:10.1111/pcmr.13064

BoRdeaux Institute in onCology [Inserm U1312 - BRIC]

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Article de revue

Ce document a été publié dans

Pigment Cell & Melanoma research. 2023-01-01, vol. 36, n° 1, p. 78-85

Résumé en anglais

Segmental vitiligo (SV) is a unilateral subtype of vitiligo which is clinically characterized by a cutaneous depigmentation and histologically by a melanocyte loss from the epidermis and hair follicle reservoirs. To date, its pathogenesis remains a mystery. In many cases, this skin depigmentation shares several clinical features and dysfunctions with herpes zoster (HZ). So, for the first time, we examined whether any nucleus and cell fusion associated with a positive immunolabelling of varicella-zoster virus (VZV) and VZV mature virions could be found in SV skin samples as in herpes zoster (HZ). A total of 40 SV samples were used for histological and immunochemical studies. Control samples were obtained from three HZ, and 10 generalized vitiligo lesions. For ultrastructural study, three recent SV and one HZ as controls were recruited. Here, we report that nuclear fusion in epidermal cells were statistically associated with recent SV (p < .001), whereas syncytia formation was associated with long-lasting SV (p = .001). A positive detection of VZV antigen was statistically associated in the epidermis with recent SV and in the dermis with long-lasting SV (p = .001). Finally, the discovery of mature virions in 3/3 recent SV samples provides additional arguments for our viral hypothesis.< Réduire

Mots clés en anglais

Humans

Herpesvirus 3

Human

Vitiligo

Skin

Herpes Zoster

Melanocytes

URI

https://oskar-bordeaux.fr/handle/20.500.12278/202024

DOI

http://dx.doi.org/10.1111/pcmr.13064

Unités de recherche

MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234

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Varicella-zoster virus in actively spreading segmental vitiligo skin: Pathological, immunochemical, and ultrastructural findings (a first and preliminary study).

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Résumé en anglais

Mots clés en anglais

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