ABIDI, Wiem; TORRES-SANCHEZ, Lucia; SIROY, Axel; KRASTEVA, Petya Violinova

doi:10.1093/femsre/fuab051

TORRES-SANCHEZ, Lucia
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]

SIROY, Axel
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]

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Article de revue

Ce document a été publié dans

FEMS Microbiology Reviews. 2021-10-21, vol. 46, n° 2

Résumé en anglais

Cellulose is the most abundant biological compound on Earth and while it is the predominant building constituent of plants, it is also a key extracellular matrix component in many diverse bacterial species. While bacterial cellulose was first described in the 19th century, it was not until this last decade that a string of structural works provided insights into how the cellulose synthase BcsA, assisted by its inner-membrane partner BcsB, senses c-di-GMP to simultaneously polymerize its substrate and extrude the nascent polysaccharide across the inner bacterial membrane. It is now established that bacterial cellulose can be produced by several distinct types of cellulose secretion systems and that in addition to BcsAB, they can feature multiple accessory subunits, often indispensable for polysaccharide production. Importantly, the last years mark significant progress in our understanding not only of cellulose polymerization per se but also of the bigger picture of bacterial signaling, secretion system assembly, biofilm formation and host tissue colonization, as well as of structural and functional parallels of this dominant biosynthetic process between the bacterial and eukaryotic domains of life. Here, we review current mechanistic knowledge on bacterial cellulose secretion with focus on the structure, assembly and cooperativity of Bcs secretion system components.< Réduire

Mots clés en anglais

Biofilm formation

Matrix exopolysaccharides

Bacterial cellulose secretion (Bcs)

C-di-GMP signaling

Synthase-dependent systems

URI

https://oskar-bordeaux.fr/handle/20.500.12278/201675

DOI

http://dx.doi.org/10.1093/femsre/fuab051

Projet Européen

Combinatorial Set Theory

Unités de recherche

CBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248

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Weaving of bacterial cellulose by the Bcs secretion systems