MILENKOVIC, Dragan; KRGA, Irena; DINEL, Anne-Laure; MORAND, Christine; LAYE, Sophie; CASTANON, Nathalie

doi:10.1016/j.jff.2021.104609

Nutrition et Neurobiologie intégrée [NutriNeuro]

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Ce document a été publié dans

Journal of Functional Foods. 2021-10-01, vol. 85, p. 104609

Résumé en anglais

Dietary anthocyanins may slow cognitive decline, improve cognitive performance and exert neuroprotective effects against neurodegenerative disorders. However, the underlying mechanisms of their action are not fully understood. This study investigated the effects of 12-week anthocyanin-rich bilberry extract supplementation (0.02%) on global gene expression in the hippocampus of ApoE-/- mice to help the understanding of molecular mechanisms underlying anthocyanin neuroprotective effects. Gene expression analysis identified 1698 differently expressed genes, with 611 downregulated and 1087 upregulated genes. Bioinformatics revealed that these genes regulate different biological processes, including neurogenesis, inflammation, metabolism, cell to cell adhesion, cytoskeleton organization, and Alzheimer's and Parkinson's disease pathology. The bioinformatic analysis also proposed potential miRNAs and transcription factors that could be involved in the mediation of these nutrigenomic effects. Results from molecular docking also suggested that anthocyanins could bind to top transcription factors with, as potential consequence, an impact on their gene expression regulation. Taken together, integrated analysis revealed a multi-target mode of action of anthocyanin-rich bilberry extract in the hippocampus underlying their neuroprotective properties.< Réduire

Mots clés en anglais

Anthocyanins

Bilberry extract

Nutrigenomics

Hippocampus

ApoE-/- mice

URI

https://oskar-bordeaux.fr/handle/20.500.12278/201471

DOI

http://dx.doi.org/10.1016/j.jff.2021.104609

Unités de recherche

NutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286

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Nutrigenomic modification induced by anthocyanin-rich bilberry extract in the hippocampus of ApoE-/- mice

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Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

DOI

Unités de recherche