BAKOYIANNIS, Ioannis; DUCOURNEAU, Eva Gunnel; N'DIAYE, Mateo; FERMIGIER, Alice; DUCROIX-CREPY, Celine; BOSCH-BOUJU, Clementine; COUTUREAU, Etienne; TRIFILIEFF, Pierre; FERREIRA, Guillaume

doi:10.7554/eLife.80388

BAKOYIANNIS, Ioannis
Nutrition et Neurobiologie intégrée [NutriNeuro]

DUCOURNEAU, Eva Gunnel

Nutrition et Neurobiologie intégrée [NutriNeuro]

N'DIAYE, Mateo
Nutrition et Neurobiologie intégrée [NutriNeuro]

Langue

Article de revue

Ce document a été publié dans

eLife. 2024-03-04, vol. 13

Résumé en anglais

Obesity is associated with neurocognitive dysfunction, including memory deficits. This is particularly worrisome when obesity occurs during adolescence, a maturational period for brain structures critical for cognition. In rodent models, we recently reported that memory impairments induced by obesogenic high-fat diet (HFD) intake during the periadolescent period can be reversed by chemogenetic manipulation of the ventral hippocampus (vHPC). Here, we used an intersectional viral approach in HFD-fed male mice to chemogenetically inactivate specific vHPC efferent pathways to nucleus accumbens (NAc) or medial prefrontal cortex (mPFC) during memory tasks. We first demonstrated that HFD enhanced activation of both pathways after training and that our chemogenetic approach was effective in normalizing this activation. Inactivation of the vHPC-NAc pathway rescued HFD-induced deficits in recognition but not location memory. Conversely, inactivation of the vHPC-mPFC pathway restored location but not recognition memory impairments produced by HFD. Either pathway manipulation did not affect exploration or anxiety-like behaviour. These findings suggest that HFD intake throughout adolescence impairs different types of memory through overactivation of specific hippocampal efferent pathways and that targeting these overactive pathways has therapeutic potential.< Réduire

Mots clés en anglais

Male

Animals

Mice

Diet

High-Fat

Obesity

Hippocampus

Anxiety

Memory Disorders

URI

https://oskar-bordeaux.fr/handle/20.500.12278/201421

DOI

http://dx.doi.org/10.7554/eLife.80388

Project ANR

Bases neuronales du comportement dirigé vers un but chez le Rat
Impact neuro-cognitif de l'obésité juvénile: approches expérimentale et clinique
Représentation sensorielle lors d'états psychotiques - ANR-16-CE37-0010

Unités de recherche

NutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286

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Obesogenic diet induces circuit-specific memory deficits in mice