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Decreased telomere length in a subgroup of young individuals with bipolar disorders: replication in the FACE-BD cohort and association with the shelterin component POT1
Idioma
EN
Article de revue
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Translational Psychiatry. 2024-03-01, vol. 14, n° 1, p. 131
Resumen en inglés
Bipolar disorder (BD) has been associated with premature cellular aging with shortened telomere length (TL) as compared to the general population. We recently identified a subgroup of young individuals with prematurely ...Leer más >
Bipolar disorder (BD) has been associated with premature cellular aging with shortened telomere length (TL) as compared to the general population. We recently identified a subgroup of young individuals with prematurely shortened TL. The aims of the present study were to replicate this observation in a larger sample and analyze the expression levels of genes associated with age or TL in a subsample of these individuals. TL was measured on peripheral blood DNA using quantitative polymerase chain reaction in a sample of 542 individuals with BD and clustering analyses were performed. Gene expression level of 29 genes, associated with aging or with telomere maintenance, was analyzed in RNA samples from a subsample of 129 individuals. Clustering analyses identified a group of young individuals (mean age 29.64 years), with shorter TL. None of the tested clinical variables were significantly associated with this subgroup. Gene expression level analyses showed significant downregulation of MYC, POT1, and CD27 in the prematurely aged young individuals compared to the young individuals with longer TL. After adjustment only POT1 remained significantly differentially expressed between the two groups of young individuals. This study confirms the existence of a subgroup of young individuals with BD with shortened TL. The observed decrease of POT1 expression level suggests a newly described cellular mechanism in individuals with BD, that may contribute to telomere shortening.< Leer menos
Palabras clave en inglés
Adult
Aged
Humans
Aging
Aging
Premature
Bipolar Disorder
Shelterin Complex
Telomere
Telomere Shortening
Telomere-Binding Proteins
Proyecto ANR
Sorbonne Universités à Paris pour l'Enseignement et la Recherche
FondaMental-Cohortes - ANR-10-COHO-0010
FondaMental-Cohortes - ANR-10-COHO-0010
Centros de investigación