Recommandations formalisées d’experts de l’AFPBN pour la prise en charge des troubles dépressifs avec réponses partielles et résistantes : mise à jour 2024

YRONDI, Antoine; JAVELOT, Herve; NOBILE, Benedicte; BOUDIEU, Ludivine; AOUIZERATE, Bruno; LLORCA, Pierre-Michel; CHARPEAUD, Thomas; BENNABI, Djamila; LEFRERE, Antoine; SAMALIN, Ludovic

doi:10.1016/j.encep.2023.11.029

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L'Encéphale. 2024-02-17

Résumé en anglais

The purpose of this update is to add newly approved nomenclatures and treatments as well as treatments yet to be approved in major depressive disorder, thus expanding the discussions on the integration of resistance factors into the clinical approach. Unlike the first consensus guidelines based on the RAND/UCLA Appropriateness Method, the French Association for Biological Psychiatry and Neuropsychopharmacology (AFPBN) developed an update of these guidelines for the management of partially responsive depression (PRD) and treatment-resistant depression (TRD). The expert guidelines combine scientific evidence and expert clinicians' opinions to produce recommendations for PRD and TRD. The recommendations addressed three areas judged as essential for updating the previous 2019 AFPBN guidelines for the management of patients with TRD: (1) the identification of risk factors associated with TRD, (2) the therapeutic management of patients with PRD and TRD, and (3) the indications, the modalities of use and the monitoring of recent glutamate receptor modulating agents (esketamine and ketamine). These consensus-based guidelines make it possible to build bridges between the available empirical literature and clinical practice, with a highlight on the 'real world' of the clinical practice, supported by a pragmatic approach centred on the experience of specialised prescribers in TRD.< Réduire

Mots clés

Dépression résistante

Dépression avec réponse partielle

Recommandation professionnelle

Pharmacothérapie

Troubles dépressifs

Mots clés en anglais

Treatment resistant depression

Partially responsive depression

Expert consensus guidelines

Pharmacotherapy

Major depressive disorder

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