LEFEVRE ARBOGAST, Sophie; CHAKER, J.; MERCIER, F.; BAROUKI, R.; COUMOUL, X.; MILLER, G. W.; DAVID, A.; SAMIERI, Cecilia

doi:10.1038/s41593-024-01627-1

Bordeaux population health [BPH]

CHAKER, J.

MERCIER, F.

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Article de revue

Ce document a été publié dans

Nature Neuroscience. 2024-05-01, vol. 27, n° 5, p. 812-821

Résumé en anglais

Over the past few decades, numerous environmental chemicals from solvents to pesticides have been suggested to be involved in the development and progression of neurodegenerative diseases. Most of the evidence has accumulated from occupational or cohort studies in humans or laboratory research in animal models, with a range of chemicals being implicated. What has been missing is a systematic approach analogous to genome-wide association studies, which have identified dozens of genes involved in Alzheimer's disease, Parkinson's disease and other neurodegenerative diseases. Fortunately, it is now possible to study hundreds to thousands of chemical features under the exposome framework. This Perspective explores how advances in mass spectrometry make it possible to generate exposomic data to complement genomic data and thereby better understand neurodegenerative diseases. Nongenetic factors contribute to the onset, progression and severity of neurodegenerative diseases. Here, the authors describe how exposomics, the systematic analysis of environmental factors, can help neuroscientists understand these diseases.< Réduire

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https://oskar-bordeaux.fr/handle/20.500.12278/201216

DOI

http://dx.doi.org/10.1038/s41593-024-01627-1

Unités de recherche

Bordeaux Population Health Research Center (BPH) - UMR 1219

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Assessing the contribution of the chemical exposome to neurodegenerative disease

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Résumé en anglais

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