Assessing the contribution of the chemical exposome to neurodegenerative disease
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | LEFEVRE ARBOGAST, Sophie | |
| dc.contributor.author | CHAKER, J. | |
| dc.contributor.author | MERCIER, F. | |
| dc.contributor.author | BAROUKI, R. | |
| dc.contributor.author | COUMOUL, X. | |
| dc.contributor.author | MILLER, G. W. | |
| dc.contributor.author | DAVID, A. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | SAMIERI, Cecilia | |
| dc.date.accessioned | 2024-08-21T08:59:52Z | |
| dc.date.available | 2024-08-21T08:59:52Z | |
| dc.date.issued | 2024-05-01 | |
| dc.identifier.issn | 1546-1726 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/201216 | |
| dc.description.abstractEn | Over the past few decades, numerous environmental chemicals from solvents to pesticides have been suggested to be involved in the development and progression of neurodegenerative diseases. Most of the evidence has accumulated from occupational or cohort studies in humans or laboratory research in animal models, with a range of chemicals being implicated. What has been missing is a systematic approach analogous to genome-wide association studies, which have identified dozens of genes involved in Alzheimer's disease, Parkinson's disease and other neurodegenerative diseases. Fortunately, it is now possible to study hundreds to thousands of chemical features under the exposome framework. This Perspective explores how advances in mass spectrometry make it possible to generate exposomic data to complement genomic data and thereby better understand neurodegenerative diseases. Nongenetic factors contribute to the onset, progression and severity of neurodegenerative diseases. Here, the authors describe how exposomics, the systematic analysis of environmental factors, can help neuroscientists understand these diseases. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/us/ | * |
| dc.title.en | Assessing the contribution of the chemical exposome to neurodegenerative disease | |
| dc.title.alternative | Nat Neurosci | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1038/s41593-024-01627-1 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 38684891 | en_US |
| bordeaux.journal | Nature Neuroscience | en_US |
| bordeaux.page | 812-821 | en_US |
| bordeaux.volume | 27 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 5 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | ELEANOR_BPH | en_US |
| bordeaux.team | LEHA_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Fondation de France | en_US |
| bordeaux.identifier.funderID | Fondation pour la Recherche Médicale | en_US |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Neuroscience&rft.date=2024-05-01&rft.volume=27&rft.issue=5&rft.spage=812-821&rft.epage=812-821&rft.eissn=1546-1726&rft.issn=1546-1726&rft.au=LEFEVRE%20ARBOGAST,%20Sophie&CHAKER,%20J.&MERCIER,%20F.&BAROUKI,%20R.&COUMOUL,%20X.&rft.genre=article |
