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Nucleus accumbens D1- and D2-expressing neurons control the balance between feeding and activity-mediated energy expenditure.

dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorWALLE, Roman
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorPETITBON, Anna
dc.contributor.authorFOIS, Giulia R
dc.contributor.authorVARIN, Christophe
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMONTALBAN, Enrica
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorHARDT, Lola
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorCONTINI, Andrea
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorANGELO, Maria Florencia
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorPOTIER, Mylène
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorORTOLE, Rodrigue
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorOUMMADI, Asma
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDE SMEDT-PEYRUSSE, Veronique
dc.contributor.authorADAN, Roger A
dc.contributor.authorGIROS, Bruno
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorCHAOULOFF, Francis
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorFERREIRA, Guillaume
dc.contributor.authorDE KERCHOVE D'EXAERDE, Alban
dc.contributor.authorDUCROCQ, Fabien
dc.contributor.authorGEORGES, François
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorTRIFILIEFF, Pierre
dc.date.accessioned2024-08-19T13:36:56Z
dc.date.available2024-08-19T13:36:56Z
dc.date.issued2024-03-21
dc.identifier.issn2041-1723en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/201174
dc.description.abstractEnAccumulating evidence points to dysregulations of the Nucleus Accumbens (NAc) in eating disorders (ED), however its precise contribution to ED symptomatic dimensions remains unclear. Using chemogenetic manipulations in male mice, we found that activity of dopamine D1 receptor-expressing neurons of the NAc core subregion facilitated effort for a food reward as well as voluntary exercise, but decreased food intake, while D2-expressing neurons have opposite effects. These effects are congruent with D2-neurons being more active than D1-neurons during feeding while it is the opposite during running. Chronic manipulations of each subpopulations had limited effects on energy balance. However, repeated activation of D1-neurons combined with inhibition of D2-neurons biased behavior toward activity-related energy expenditure, whilst the opposite manipulations favored energy intake. Strikingly, concomitant activation of D1-neurons and inhibition of D2-neurons precipitated weight loss in anorexia models. These results suggest that dysregulations of NAc dopaminoceptive neurons might be at the core of EDs.
dc.description.sponsorshipDéveloppement d'une infrastructure française distribuée coordonnée - ANR-10-INBS-0004en_US
dc.description.sponsorshipInitiative d'excellence de l'Université de Bordeauxen_US
dc.description.sponsorshipImpact de la composition lipidique membranaire sur la transmission dopaminergique dépendante du récepteur D2 et la motivationen_US
dc.description.sponsorshipRole du biostatus en acides gras polyinsaturés dans les troubles de contrôle exécutifen_US
dc.description.sponsorshipRôle du circuit POMC-striatum ventral dans le développement de l'obésité - ANR-21-CE14-0018en_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enMice
dc.subject.enMale
dc.subject.enAnimals
dc.subject.enNucleus Accumbens
dc.subject.enReceptors
dc.subject.enDopamine D2
dc.subject.enNeurons
dc.subject.enReceptors
dc.subject.enDopamine D1
dc.subject.enEnergy Metabolism
dc.title.enNucleus accumbens D1- and D2-expressing neurons control the balance between feeding and activity-mediated energy expenditure.
dc.title.alternativeNat Communen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41467-024-46874-9en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed38514654en_US
bordeaux.journalNature Communicationsen_US
bordeaux.page2543en_US
bordeaux.volume15en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcepubmed
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Communications&rft.date=2024-03-21&rft.volume=15&rft.issue=1&rft.spage=2543&rft.epage=2543&rft.eissn=2041-1723&rft.issn=2041-1723&rft.au=WALLE,%20Roman&PETITBON,%20Anna&FOIS,%20Giulia%20R&VARIN,%20Christophe&MONTALBAN,%20Enrica&rft.genre=article


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