AZHIKKATTUPARAMBIL BHASKARAN, Arjun; GAUVRIT, Théo; VYAS, Yukti; BONY, Guillaume; GINGER, Mélanie; FRICK, Andreas

doi:10.1038/s41467-023-43777-z

AZHIKKATTUPARAMBIL BHASKARAN, Arjun
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

GAUVRIT, Théo
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

VYAS, Yukti
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

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Article de revue

Ce document a été publié dans

Nature Communications. 2023-11-30, vol. 14, n° 1

Résumé en anglais

Excessive neural variability of sensory responses is a hallmark of atypical sensory processing in autistic individuals with cascading effects on other core autism symptoms but unknown neurobiological substrate. Here, by recording neocortical single neuron activity in a well-established mouse model of Fragile X syndrome and autism, we characterized atypical sensory processing and probed the role of endogenous noise sources in exaggerated response variability in males. The analysis of sensory stimulus evoked activity and spontaneous dynamics, as well as neuronal features, reveals a complex cellular and network phenotype. Neocortical sensory information processing is more variable and temporally imprecise. Increased trial-by-trial and inter-neuronal response variability is strongly related to key endogenous noise features, and may give rise to behavioural sensory responsiveness variability in autism. We provide a novel preclinical framework for understanding the sources of endogenous noise and its contribution to core autism symptoms, and for testing the functional consequences for mechanism-based manipulation of noise. © 2023, The Author(s).< Réduire

Mots clés en anglais

Autistic Disorder

Disease Models

Animal

Fragile X Mental Retardation Protein

Fragile X Syndrome

Male

Mice

Knockout

Neocortex

Neurons

Sensation

Fmr1 protein

Mouse

URI

https://oskar-bordeaux.fr/handle/20.500.12278/201039

DOI

http://dx.doi.org/10.1038/s41467-023-43777-z

Unités de recherche

Neurocentre Magendie - U1215

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Endogenous noise of neocortical neurons correlates with atypical sensory response variability in the Fmr1 −/y mouse model of autism

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Résumé en anglais

Mots clés en anglais

URI

DOI

Unités de recherche