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dc.rights.licenseopenen_US
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorAZHIKKATTUPARAMBIL BHASKARAN, Arjun
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorGAUVRIT, Théo
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorVYAS, Yukti
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorBONY, Guillaume
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorGINGER, Mélanie
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorFRICK, Andreas
dc.date.accessioned2024-07-19T13:36:15Z
dc.date.available2024-07-19T13:36:15Z
dc.date.issued2023-11-30
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/201039
dc.description.abstractEnExcessive neural variability of sensory responses is a hallmark of atypical sensory processing in autistic individuals with cascading effects on other core autism symptoms but unknown neurobiological substrate. Here, by recording neocortical single neuron activity in a well-established mouse model of Fragile X syndrome and autism, we characterized atypical sensory processing and probed the role of endogenous noise sources in exaggerated response variability in males. The analysis of sensory stimulus evoked activity and spontaneous dynamics, as well as neuronal features, reveals a complex cellular and network phenotype. Neocortical sensory information processing is more variable and temporally imprecise. Increased trial-by-trial and inter-neuronal response variability is strongly related to key endogenous noise features, and may give rise to behavioural sensory responsiveness variability in autism. We provide a novel preclinical framework for understanding the sources of endogenous noise and its contribution to core autism symptoms, and for testing the functional consequences for mechanism-based manipulation of noise. © 2023, The Author(s).
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enAutistic Disorder
dc.subject.enDisease Models
dc.subject.enAnimal
dc.subject.enFragile X Mental Retardation Protein
dc.subject.enFragile X Syndrome
dc.subject.enMale
dc.subject.enMice
dc.subject.enKnockout
dc.subject.enNeocortex
dc.subject.enNeurons
dc.subject.enSensation
dc.subject.enFmr1 protein
dc.subject.enMouse
dc.title.enEndogenous noise of neocortical neurons correlates with atypical sensory response variability in the Fmr1 −/y mouse model of autism
dc.title.alternativeNat Communen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41467-023-43777-zen_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed38036566en_US
bordeaux.journalNature Communicationsen_US
bordeaux.volume14en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamPlasticité Corticaleen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
hal.identifierhal-04654386
hal.version1
hal.date.transferred2024-07-19T13:36:18Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Communications&rft.date=2023-11-30&rft.volume=14&rft.issue=1&rft.au=AZHIKKATTUPARAMBIL%20BHASKARAN,%20Arjun&GAUVRIT,%20Th%C3%A9o&VYAS,%20Yukti&BONY,%20Guillaume&GINGER,%20M%C3%A9lanie&rft.genre=article


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