Photosensitizer localization in amphiphilic block copolymers controls photodynamic therapy efficacy
IBRAHIMOVA, Vusala
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Institut de la matière condensée et des nanosciences / Institute of Condensed Matter and Nanosciences [IMCN]
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Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Institut de la matière condensée et des nanosciences / Institute of Condensed Matter and Nanosciences [IMCN]
IBRAHIMOVA, Vusala
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Institut de la matière condensée et des nanosciences / Institute of Condensed Matter and Nanosciences [IMCN]
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Institut de la matière condensée et des nanosciences / Institute of Condensed Matter and Nanosciences [IMCN]
LECOMMANDOUX, Sebastien
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Laboratoire de Chimie des Polymères Organiques [LCPO]
FUSTIN, Charles-André
Institut de la matière condensée et des nanosciences / Institute of Condensed Matter and Nanosciences [IMCN]
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Institut de la matière condensée et des nanosciences / Institute of Condensed Matter and Nanosciences [IMCN]
Langue
en
Article de revue
Ce document a été publié dans
Nanoscale. 2017, vol. 9, n° 31, p. 11180-11186
Royal Society of Chemistry
Résumé en anglais
Localization of the photosensitizer conjugation site in amphiphilic block copolymers is shown to have a great impact on photodynamic therapy efficiency. To this end, an asymmetric multifunctional derivative of the ...Lire la suite >
Localization of the photosensitizer conjugation site in amphiphilic block copolymers is shown to have a great impact on photodynamic therapy efficiency. To this end, an asymmetric multifunctional derivative of the azadipyrromethene boron difluoride chelate (aza-BODIPY) was synthesized and inserted at specific locations in polypeptide-based rod-coil amphiphilic block copolymers. A study of the photophysical properties of the vesicle nanocarriers, obtained by self-assembly of these copolymers, as well as in vitro tests on two cancer cell lines were performed. This study aims at providing guidelines for the optimization of the synthetic design of therapeutic nanomedicines with minimal amounts of photosensitive molecules.< Réduire
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