IBRAHIMOVA, Vusala; DENISOV, Sergey A.; VANVARENBERG, Kevin; VERWILST, Peter; PRÉAT, Véronique; GUIGNER, Jean-Michel; MCCLENAGHAN, Nathan; LECOMMANDOUX, Sebastien; FUSTIN, Charles-André

doi:10.1039/C7NR04403H

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IBRAHIMOVA, Vusala
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Institut de la matière condensée et des nanosciences / Institute of Condensed Matter and Nanosciences [IMCN]

DENISOV, Sergey A.
Institut des Sciences Moléculaires [ISM]

VANVARENBERG, Kevin
Unité de Pharmacologie Cellulaire et Moléculaire [Brussels]

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Nanoscale. 2017, vol. 9, n° 31, p. 11180-11186

Royal Society of Chemistry

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Localization of the photosensitizer conjugation site in amphiphilic block copolymers is shown to have a great impact on photodynamic therapy efficiency. To this end, an asymmetric multifunctional derivative of the azadipyrromethene boron difluoride chelate (aza-BODIPY) was synthesized and inserted at specific locations in polypeptide-based rod-coil amphiphilic block copolymers. A study of the photophysical properties of the vesicle nanocarriers, obtained by self-assembly of these copolymers, as well as in vitro tests on two cancer cell lines were performed. This study aims at providing guidelines for the optimization of the synthetic design of therapeutic nanomedicines with minimal amounts of photosensitive molecules.< Leer menos

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Photosensitizer localization in amphiphilic block copolymers controls photodynamic therapy efficacy

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