LOUBET, Paul; LELIEVRE, Jean-Daniel; FRANCOIS, Alexis; BOTELHO-NEVERS, Elisabeth; CHIDIAC, Christian; CHIRIO, David; DUBEE, Vincent; DUSSOL, Bertrand; GALTIER, Florence; HESSAMFAR, Mojgan; HODAJ, Enkelejda; JAFFUEL, Sylvain; LACOMBE, Karine; LAINE, Fabrice; LEFEBVRE, Maeva; MAAKAROUN-VERMESSE, Zoha; MAKINSON, Alain; PORTEFAIX, Aurelie; POURCHER, Valerie; REY, David; ZUCMAN, David; LONGOBARDI, Julie; BERTHEAU, Mathilde; TARTOUR, Eric; DE LAMBALLERIE, Xavier; LAUNAY, Odile; WITTKOP, Linda

doi:10.1016/j.ijid.2024.107110

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International Journal of Infectious Diseases. 2024-05-31, vol. 146, p. 107110

Résumé en anglais

BACKGROUND: This study aimed to compare the humoral responses to mRNA COVID-19 vaccination in PWH and HIV-negative individuals. METHODS: We included PWH with an undetectable viral load under ART and HIV-negative participants from the French nationwide ANRS COV-POPART cohort who had received two doses of vaccine as a primary vaccination. We compared humoral response between controls and PWH, stratified by CD4 cell count (< 200/mm(3) and ≥ 200/mm(3) CD4 cell counts) at 1, 6 and 12 months after primary vaccination. RESULTS: A total of 1776 participants were included in this analysis, 684 PWH (99% were on ART, median CD4 counts 673 cells/mm(3)) and 1092 controls. At 1 month, after adjustment on age, sex and BMI, PWH had lower seroneutralization titers than controls and PWH with < 200 CD4 cell/mm3 had lower anti- Spike SARS-CoV-2 IgG antibodies. Same results were found at 6 months. However, in participants who received a booster dose between 6 and 12 months post primary vaccination, we did not observe differences between PWH and controls at 12 months. CONCLUSION: PWH had high responses to primary mRNA COVID-19 vaccination. In those who received a booster dose after six months, the humoral response at 12 months increased to similar levels to controls, even in those with low CD4 counts at baseline.< Réduire

Mots clés en anglais

COVID-19

HIV

Immunogenicity

SARS-CoV-2

Vaccines

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https://oskar-bordeaux.fr/handle/20.500.12278/200677

DOI

http://dx.doi.org/10.1016/j.ijid.2024.107110

Unités de recherche

Bordeaux Population Health Research Center (BPH) - UMR 1219

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Humoral response after mRNA COVID-19 primary vaccination and single booster dose in people living with HIV compared to controls: a French nationwide multicenter cohort study - ANRS0001s COV-POPART

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