Afficher la notice abrégée

Humoral response after mRNA COVID-19 primary vaccination and single booster dose in people living with HIV compared to controls: a French nationwide multicenter cohort study - ANRS0001s COV-POPART

dc.rights.licenseopenen_US
dc.contributor.authorLOUBET, Paul
dc.contributor.authorLELIEVRE, Jean-Daniel
dc.contributor.authorFRANCOIS, Alexis
dc.contributor.authorBOTELHO-NEVERS, Elisabeth
dc.contributor.authorCHIDIAC, Christian
dc.contributor.authorCHIRIO, David
dc.contributor.authorDUBEE, Vincent
dc.contributor.authorDUSSOL, Bertrand
dc.contributor.authorGALTIER, Florence
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHESSAMFAR, Mojgan
dc.contributor.authorHODAJ, Enkelejda
dc.contributor.authorJAFFUEL, Sylvain
dc.contributor.authorLACOMBE, Karine
dc.contributor.authorLAINE, Fabrice
dc.contributor.authorLEFEBVRE, Maeva
dc.contributor.authorMAAKAROUN-VERMESSE, Zoha
dc.contributor.authorMAKINSON, Alain
dc.contributor.authorPORTEFAIX, Aurelie
dc.contributor.authorPOURCHER, Valerie
dc.contributor.authorREY, David
dc.contributor.authorZUCMAN, David
dc.contributor.authorLONGOBARDI, Julie
dc.contributor.authorBERTHEAU, Mathilde
dc.contributor.authorTARTOUR, Eric
dc.contributor.authorDE LAMBALLERIE, Xavier
dc.contributor.authorLAUNAY, Odile
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorWITTKOP, Linda
dc.date.accessioned2024-06-27T13:46:57Z
dc.date.available2024-06-27T13:46:57Z
dc.date.issued2024-05-31
dc.identifier.issn1878-3511en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/200677
dc.description.abstractEnBACKGROUND: This study aimed to compare the humoral responses to mRNA COVID-19 vaccination in PWH and HIV-negative individuals. METHODS: We included PWH with an undetectable viral load under ART and HIV-negative participants from the French nationwide ANRS COV-POPART cohort who had received two doses of vaccine as a primary vaccination. We compared humoral response between controls and PWH, stratified by CD4 cell count (< 200/mm(3) and ≥ 200/mm(3) CD4 cell counts) at 1, 6 and 12 months after primary vaccination. RESULTS: A total of 1776 participants were included in this analysis, 684 PWH (99% were on ART, median CD4 counts 673 cells/mm(3)) and 1092 controls. At 1 month, after adjustment on age, sex and BMI, PWH had lower seroneutralization titers than controls and PWH with < 200 CD4 cell/mm3 had lower anti- Spike SARS-CoV-2 IgG antibodies. Same results were found at 6 months. However, in participants who received a booster dose between 6 and 12 months post primary vaccination, we did not observe differences between PWH and controls at 12 months. CONCLUSION: PWH had high responses to primary mRNA COVID-19 vaccination. In those who received a booster dose after six months, the humoral response at 12 months increased to similar levels to controls, even in those with low CD4 counts at baseline.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enCOVID-19
dc.subject.enHIV
dc.subject.enImmunogenicity
dc.subject.enSARS-CoV-2
dc.subject.enVaccines
dc.title.enHumoral response after mRNA COVID-19 primary vaccination and single booster dose in people living with HIV compared to controls: a French nationwide multicenter cohort study - ANRS0001s COV-POPART
dc.title.alternativeInt J Infect Disen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.ijid.2024.107110en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed38825164en_US
bordeaux.journalInternational Journal of Infectious Diseasesen_US
bordeaux.page107110en_US
bordeaux.volume146en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionINRIAen_US
bordeaux.teamSISTM_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAgence Nationale de Recherches sur le Sida et les Hépatites Viralesen_US
hal.identifierhal-04627501
hal.version1
hal.date.transferred2024-06-27T13:47:01Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=International%20Journal%20of%20Infectious%20Diseases&amp;rft.date=2024-05-31&amp;rft.volume=146&amp;rft.spage=107110&amp;rft.epage=107110&amp;rft.eissn=1878-3511&amp;rft.issn=1878-3511&amp;rft.au=LOUBET,%20Paul&amp;LELIEVRE,%20Jean-Daniel&amp;FRANCOIS,%20Alexis&amp;BOTELHO-NEVERS,%20Elisabeth&amp;CHIDIAC,%20Christian&amp;rft.genre=article


Fichier(s) constituant ce document

Thumbnail
Nom:
BPH_IntJInfectDis_2024_Loubet.pdf
Taille:
1.921Mo
Format:
PDF
Voir/Ouvrir
Thumbnail
Nom:
license_rdf
Taille:
914octets
Format:
application/rdf+xml
Voir/Ouvrir

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée