ABARKAN, Myriam; FOIS, Giulia; VOUILLAC-MENDOZA, Caroline; AHMED, Serge; GUILLEM, Karine

doi:10.1038/s41386-022-01428-9

Métadonnées

Afficher la notice complète

Licence d’utilisation du document

ABARKAN, Myriam

Chimie et Biologie des Membranes et des Nanoobjets [CBMN]

FOIS, Giulia
Institut des Maladies Neurodégénératives [Bordeaux] [IMN]

VOUILLAC-MENDOZA, Caroline
Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]

Langue

Article de revue

Ce document a été publié dans

Neuropsychopharmacology. 2023, vol. 48, n° 6, p. 887-896

Résumé en anglais

Nicotine addiction develops after prolonged drug use and escalation of drug intake. However, because of difficulties in demonstrating escalation of nicotine use in rats, its underlying neuroadaptations still remain poorly understood. Here we report that access to unusually high doses of nicotine (i.e., from 30 µg to 240 µg/kg/injection) for self-administration precipitated a rapid and robust escalation of nicotine intake and increased the motivation for the drug in rats. This nicotine intake escalation also induced long-lasting changes in vmPFC neuronal activity both before and during nicotine self-administration. Specifically, after escalation of nicotine intake, basal vmPFC neuronal activity increased above pre-escalation and control activity levels, while ongoing nicotine self-administration restored these neuronal changes. Finally, simulation of the restoring effects of nicotine with in vivo optogenetic inhibition of vmPFC neurons caused a selective de-escalation of nicotine self-administration.< Réduire

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Altered neuronal activity in the ventromedial prefrontal cortex drives nicotine intake escalation

Langue

Ce document a été publié dans

Résumé en anglais

URI

DOI

Unités de recherche