ERCICEK, Fatma; HARSCOAT-SCHIAVO, Christelle; LAYRISSE, Patrick; MARCHIVIE, Mathieu; CARTIGNY, Yohann; BRANDEL, Clement; TASSAING, Thierry; CONRAD, Max; MARRE, Samuel; SUBRA-PATERNAULT, Pascale

doi:10.1016/j.supflu.2023.105976

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ERCICEK, Fatma

Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]

HARSCOAT-SCHIAVO, Christelle
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]

LAYRISSE, Patrick
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]

Langue

Article de revue

Ce document a été publié dans

Journal of Supercritical Fluids. 2023, vol. 200, p. 105976

Résumé en anglais

Cocrystals of S-naproxen (S-NPX) or RS-naproxen (RS-NPX) and 4,4′bipyridine (BiPY) were prepared by the Gaseous Anti Solvent (GAS) method using CO2 as antisolvent. S-NPX and BiPY cocrystals were also produced by Cocrystallization with Supercritical Solvent (CSS) using CO2 as a solvent though leading to mixtures of cocrystals and homocrystals. Hydrogen-bond networks and stoichiometries of produced cocrystals were identical whatever the mode of preparation (evaporation, grinding and CO2-assisted processes) and matched those already described in literature: S-NPX2:BiPY1 and RS-NPX2:BiPY1. The effects of the NPX:BiPY molar ratio and of the processing conditions were investigated. By GAS, an excess of BiPY in the initial processed mixture was mandatory to produce pure S-NPX2:BiPY1 cocrystals whereas pure RS-NPX2:BiPY1 cocrystals were identically produced from mixtures of 2:2 and 2:1 NPX:BiPY initial ratio. No enrichment of the product in any of the naproxen enantiomer was reached, even when mixtures of S- + RS-NPX were coprocessed with bipyridine.< Réduire

Mots clés en anglais

Cocrystal

CO2

crystallization

naproxen

bipyridine

antisolvent

URI

https://oskar-bordeaux.fr/handle/20.500.12278/199532

DOI

http://dx.doi.org/10.1016/j.supflu.2023.105976

Project ANR

Apport du CO2 dans le contrôle de phase cristalline - ANR-18-CE07-0047

Unités de recherche

CBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248