KOEHLER, Victor; BRUSCHERA, Gabrielle; MERLET, Eric; MANDAL, Pradeep; MORVAN, Estelle; ROSU, Frederic; DOUAT, Celine; FISCHER, Lucile; HUC, Ivan; FERRAND, Yann

doi:10.1002/anie.202311639

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KOEHLER, Victor

Chimie et Biologie des Membranes et des Nanoobjets [CBMN]

BRUSCHERA, Gabrielle
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]

MERLET, Eric
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]

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Article de revue

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Angewandte Chemie International Edition. 2023

Resumen en inglés

We prepared a series of water‐soluble aromatic oligoamide sequences all composed of a segment prone to form a single helix and a segment prone to dimerize into a double helix. These sequences exclusively assemble as antiparallel duplexes. The modification of the duplex inner rim by varying the nature of the substituents borne by the aromatic monomers allowed us to identify sequences that can hybridize by combining two chemically different strands, with high affinity and complete selectivity in water. X‐ray crystallography confirmed the expected antiparallel configuration of the duplexes whereas NMR spectroscopy and mass spectrometry allowed us to assess precisely the extent of the hybridization. The hybridization kinetics of the aromatic strands was shown to depend on both the nature of the substituents responsible for strand complementarity and the length of the aromatic strand. These results highlight the great potential of aromatic hetero‐duplexes as a tool to construct non‐symmetrical dynamic supramolecular assemblies.< Leer menos

URI

https://oskar-bordeaux.fr/handle/20.500.12278/199529

DOI

http://dx.doi.org/10.1002/anie.202311639

Proyecto ANR

Assemblage dynamique de foldamères oligoamides aromatiques pour la stabilisation d'interactions protéine-protéine - ANR-19-CE07-0034

Centros de investigación

CBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248