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dc.rights.licenseopenen_US
dc.contributor.authorEL MIHYAOUI, Amina
dc.contributor.authorCHARFI, Saoulajan
dc.contributor.authorERBIAI, El Hadi
dc.contributor.authorPEREIRA, Mariana
dc.contributor.authorDUARTE, Diana
dc.contributor.authorVALE, Nuno
dc.contributor.authorCANDELA CASTILLO, María Emilia
hal.structure.identifierUnité de Recherche Œnologie [Villenave d'Ornon] [OENO]
dc.contributor.authorBADOC, Alain
dc.contributor.authorLAMARTI, Ahmed
dc.contributor.authorESTEVES DA SILVA, Joaquim C. G.
dc.contributor.authorARNAO, M.B.
dc.contributor.authorARNAO, Marino B.
dc.date.accessioned2024-04-29T10:35:37Z
dc.date.available2024-04-29T10:35:37Z
dc.date.issued2023
dc.identifier.issn2072-6694en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199365
dc.description.abstractEnMany of the chemotherapeutic drugs for the treatment of cancer are molecules identified and isolated from plants or their synthetic derivatives. This work aimed to identify the bioactive compounds using LC-MS and GC-MS and to evaluate the anticancer activity of the methanolic extracts of roots, stems, leaves, and flowers from Cladanthus mixtus. The anticancer activity was evaluated in vitro against two cancer cell lines: human breast carcinoma (MCF-7) and human prostate carcinoma (PC-3), using the MTT assay and microscopic observation. A human normal lung fibroblast (MRC-5) was included to determine the extract’s safety for non-tumoral cells. The chemical composition results by LC-MS analysis revealed the presence of 24 phenolic compounds. Furthermore, GC-MS analysis allowed the identification of many biomolecules belonging to terpenoids, esters, alcohols, alkanes, fatty acids, organic acids, benzenes, phenols, ketones, carbonyls, amines, sterols, and other groups. The findings suggest that the majority of C. mixtus extracts have antiproliferative activity against two cancer cell lines, MCF-7 and PC-3, and one non-tumoral cell line, MRC-5. The activity was dose-dependent, and the highest effect was obtained with leaf extract in the two cancer cell lines. Moreover, these extracts demonstrated an acceptable toxicological profile against normal cells. Overall, C. mixtus extracts revealed promising antitumor properties provided by their phytochemical composition. © 2022 by the authors.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enAnticancer activity
dc.subject.enCladanthus mixtus
dc.subject.enRoots
dc.subject.enStems
dc.subject.enLeaves
dc.subject.enFlowers
dc.subject.enMTT assay
dc.subject.enPC-3 cells
dc.subject.enMCF-7 cells
dc.subject.enMRC-5 cells
dc.title.enPhytochemical Compounds and Anticancer Activity of Cladanthus mixtus Extracts from Northern Morocco
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/cancers15010152en_US
dc.subject.halSciences du Vivant [q-bio]/Biologie végétaleen_US
bordeaux.journalCancersen_US
bordeaux.volume15en_US
bordeaux.hal.laboratoriesOenologie - UMR 1366en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04562658
hal.version1
hal.date.transferred2024-04-29T10:35:40Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cancers&rft.date=2023&rft.volume=15&rft.issue=1&rft.eissn=2072-6694&rft.issn=2072-6694&rft.au=EL%20MIHYAOUI,%20Amina&CHARFI,%20Saoulajan&ERBIAI,%20El%20Hadi&PEREIRA,%20Mariana&DUARTE,%20Diana&rft.genre=article


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