BORCHIELLINI, Paul; RAMES, Adeline; ROUBERTIE, François; L’HEUREUX, Nicolas; KAWECKI, Fabien

doi:10.1088/1758-5090/acf1cf

Bioingénierie tissulaire [BIOTIS]

RAMES, Adeline
Bioingénierie tissulaire [BIOTIS]

ROUBERTIE, François
IHU-LIRYC

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Article de revue

Ce document a été publié dans

Biofabrication. 2023-08-31, vol. 15, n° 4, p. 045018

Résumé en anglais

Abstract Most vascular surgical repair procedures, such as vessel anastomoses, requires using suture materials that are mechanically efficient and accepted by the patient’s body. These materials are essentially composed of synthetic polymers, such as polypropylene (Prolene TM ) or polyglactin (Vicryl TM ). However, once implanted in patients, they are recognized as foreign bodies, and the patient’s immune system will degrade, encapsulate, or even expel them. In this study, we developed innovative biological sutures for cardiovascular surgical repairs using Cell-Assembled extracellular Matrix (CAM)-based ribbons. After a mechanical characterization of the CAM-based ribbons, sutures were made with hydrated or twisted/dried ribbons with an initial width of 2 or 3 mm. These biological sutures were mechanically characterized and used to anastomose ex vivo animal aortas. Data showed that our biological sutures display lower permeability and higher burst resistance than standard Prolene TM suture material. In vivo carotid anastomoses realized in sheep demonstrated that our biological sutures are compatible with standard vascular surgery techniques. Echography confirmed the absence of thrombus and perfect homeostasis with no blood leakage was obtained within the first 10 min after closing the anastomosis. Finally, our findings confirmed the effectiveness and clinical relevance of these innovative biological sutures.< Réduire

Mots clés en anglais

Biological suture

Cell-assembled extracellular matrix

Anastomosis

Human textiles

URI

https://oskar-bordeaux.fr/handle/20.500.12278/199238

DOI

http://dx.doi.org/10.1088/1758-5090/acf1cf

Project ANR

Évaluation préclinique d'une valve monocusp et d'un patch transannulaire entièrement biologiques pour la correction de la tétralogie de Fallot - ANR-21-CE17-0001

Unités de recherche

Bioingénierie Tissulaire (BioTis) - U1026

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Development and characterization of biological sutures made of cell-assembled extracellular matrix