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Ultrasound assisted extraction of amino acids and nucleobases from clay minerals and astrobiological samples

hal.structure.identifierInstitut de chimie des milieux et matériaux de Poitiers [UMR 7285] [IC2MP [Poitiers]]
dc.contributor.authorTIMOUMI, Ramzi
hal.structure.identifierInstitut de chimie des milieux et matériaux de Poitiers [UMR 7285] [IC2MP [Poitiers]]
dc.contributor.authorAMANIAMPONG, Prince Nana
hal.structure.identifierLaboratoire d'Astrophysique de Bordeaux [Pessac] [LAB]
dc.contributor.authorLE POSTOLLEC, Aurelie
hal.structure.identifierLaboratoire d'Astrophysique de Bordeaux [Pessac] [LAB]
dc.contributor.authorDOBRIJEVIC, Michel
hal.structure.identifierCentre National d'Études Spatiales [Toulouse] [CNES]
dc.contributor.authorRIOLAND, Guillaume
hal.structure.identifierInstitut de chimie des milieux et matériaux de Poitiers [UMR 7285] [IC2MP [Poitiers]]
dc.contributor.authorGREGOIRE, Brian
hal.structure.identifierInstitut de chimie des milieux et matériaux de Poitiers [UMR 7285] [IC2MP [Poitiers]]
dc.contributor.authorPOINOT, Pauline
hal.structure.identifierInstitut de chimie des milieux et matériaux de Poitiers [UMR 7285] [IC2MP [Poitiers]]
dc.contributor.authorGEFFROY-RODIER, Claude
dc.date.issued2024-02
dc.identifier.issn1350-4177
dc.description.abstractEnThe design of innovative therapeutic strategies enabling the selective destruction of tumor cells while sparing healthy tissues remains highly challenging in cancer therapy. Here, we show that the combination of two targeted therapies, including bevacizumab (Bev), and a beta-glucuronidase-responsive albumin-binding prodrug of monomethyl auristatin E (MMAE), is efficient for the treatment of colorectal cancer implanted in mice. This combined therapy produces a therapeutic activity superior to that of the association of FOLFOX and Bev currently used to treat patients with this pathology. The increased anticancer efficacy is due to either a synergistic or an additive effect between Bev and MMAE selectively released from the glucuronide prodrug in the tumor microenvironment. Since numerous drug delivery systems such as antibody-drug conjugates employ MMAE as a cytotoxic payload, this finding may be of great interest for improving their therapeutic index by combining them with Bev, particularly for the therapy of colorectal cancer.
dc.description.sponsorshipIntegrative analytical unit for the study of emergent catalytic systems - ANR-22-EXOR-0014
dc.language.isoen
dc.publisherElsevier
dc.subject.enUAE Meteorite
dc.subject.enAmino acids
dc.subject.enNucleobases
dc.subject.enPeptides
dc.subject.enUltrasound frequency
dc.title.enUltrasound assisted extraction of amino acids and nucleobases from clay minerals and astrobiological samples
dc.typeArticle de revue
dc.identifier.doi10.1016/j.ultsonch.2024.106775
dc.subject.halChimie/Chimie analytique
dc.subject.halPlanète et Univers [physics]
dc.subject.halSciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Biochimie [q-bio.BM]
dc.subject.halSciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Réseaux moléculaires [q-bio.MN]
dc.subject.halSciences du Vivant [q-bio]/Cancer
bordeaux.journalUltrasonics Sonochemistry
bordeaux.page106775
bordeaux.volume103
bordeaux.peerReviewedoui
hal.identifierhal-04508237
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-04508237v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Ultrasonics%20Sonochemistry&rft.date=2024-02&rft.volume=103&rft.spage=106775&rft.epage=106775&rft.eissn=1350-4177&rft.issn=1350-4177&rft.au=TIMOUMI,%20Ramzi&AMANIAMPONG,%20Prince%20Nana&LE%20POSTOLLEC,%20Aurelie&DOBRIJEVIC,%20Michel&RIOLAND,%20Guillaume&rft.genre=article


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